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Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Aug 2023Deadline 19 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldASDATP phosphohydrolaseATPaseAccelerationAdenosine TriphosphataseAdolescentAdolescent YouthAdultAdult HumanAffectAmericanAmmon HornAnabolismAutismAutistic DisorderAxonBehaviorBehavioralBindingBinding ProteinsBiochemicalBiologicalBiologyBipolar Affective PsychosisBipolar DisorderBrainBrain Nervous SystemCell LocomotionCell MigrationCell MovementCell-Extracellular MatrixCellular MechanotransductionCellular MigrationCellular MotilityChemicalsChildhoodChondroitin 4 SulfateChondroitin 6 SulfateChondroitin Sulfate AChondroitin Sulfate BChondroitin Sulfate CChondroitin SulfatesClinical ResearchClinical StudyCodeCoding SystemConnector NeuronCornu AmmonisCoupledCuesDSCSPGDataDefectDermatan SulfateDetectionDevelopmentDiseaseDisorderECMEarly Infantile AutismElementsEncephalonEngineeringEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEventExhibitsExposure toExtracellular MatrixFiberGAGGAG GeneGene ExpressionGestationGlycansGrowth AgentsGrowth FactorGrowth SubstancesHigh Fat DietHippocampusHortega cellHypersensitivityImmuneImmune Cell ActivationImmunesImpairmentInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntervention StrategiesIsomerismKanner's SyndromeLactationLengthLigand Binding ProteinLigand Binding Protein GeneLinkManic-Depressive PsychosisMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMaternal NutritionMaternal dietMechanical Signal TransductionMechanosensory TransductionMediatingMediatorMental DepressionMental HealthMental HygieneMental disordersMental health disordersMethodologyMethodsMiceMice MammalsMicrogliaModelingMolecular InteractionMotorMurineMusNeural DevelopmentNeurodevelopmental DisorderNeuroimmuneNeurological Development DisorderPSGAGPatientsPatternPolymersPolysaccharidesPregnancyPrevalencePreventionProcessProtein BindingProteinsProteins Growth FactorsPsychiatric DiseasePsychiatric DisorderPsychological HealthRegulationReportingResolutionRiskRodentRodentiaRodents MammalsSchizophreniaSchizophrenic DisordersStimulusStructureSulfateTechniquesTechnologyZIKVZika Virusadulthoodautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon growthaxon growth cone guidanceaxon guidanceaxonal growthaxonal pathfindingbeta-Heparinbiologicbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbiosynthesisbipolar affective disorderbipolar diseasebipolar illnessbipolar mood disorderbound proteinbrain volumecell motilitycritical periodcytokinedementia praecoxdepressiondermatan sulfate chondroitin sulfatedevelopmentalearly childhoodepidemiologic investigationepidemiology studyextracellularfetalgene signaturesgenetic signaturegitter cellglycosaminoglycan polysulfateglycosaminoglycan polysulfuric acid esterglycosaminoglycan polysulphatehippocampalhydrogen sulfate Chondroitinimmune activationisomerjuvenilejuvenile humanlactatinglactationallaser capture microdissectionlater in lifelater lifemanic depressive disordermanic depressive illnessmaternal nutrition during pregnancymechanosensingmechanotransductionmental illnessmesogliamicroglial cellmicrogliocytemigrationmother nutritionmultidisciplinarynano porenanoporenanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingneurodevelopmentneurodevelopmental diseaseneuropathologicneuropathologicalneuropathologyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatrynon-human primatenonhuman primatenoveloffspringpediatricperivascular glial cellpolymerpolymericpolysulfated glycosaminoglycanpost-natal developmentpostnatalpostnatal developmentpre-clinical studypreclinical studyprenatalpreventpreventingpsychiatric illnesspsychological disorderregional differenceresolutionsresponseschizophrenicsensorsingle moleculespatial and temporalspatial temporalspatiotemporalsulfated glycosaminoglycansynapse formationsynaptogenesistheoriestranslational opportunitiestranslational potentialunbornzikav
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Description preview
ABSTRACT
Maternal immune activation (MIA) during prenatal or postnatal development significantly increases the risk for
offspring neurodevelopmental disorders (NDDs) later in life. Growing evidence suggest that regardless of the
MIA stimuli (infectious or environmental), offspring exhibit an enhanced risk for lifelong neuropathology defects…
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