grant
Maternal gut microbiota in fetal programming of neurodevelopment and related disorders
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ASDATAC sequencingATAC-seqATACseqAdoptive TransferAdverse effectsAffectAssay for Transposase-Accessible Chromatin using sequencingAutismAutistic DisorderBehaviorBehavior assessmentBehavioralBehavioral SymptomsBlood SerumBrainBrain Nervous SystemBrain regionBusinessesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell IsolationCell MaturationCell SegregationCell SeparationCell Separation TechnologyCellular Immune FunctionChronic DiseaseChronic IllnessConsensusCoupledDataDeveloping fetusDevelopmentDiathesisDietDiseaseDisease susceptibilityDisorderDysfunctionEarly Infantile AutismEmbryoEmbryonicEncephalonEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFamilyFemaleFetal DevelopmentFunctional MetagenomicsFunctional disorderGI microbiomeGI microbiotaGastrointestinal microbiotaGenerationsGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGerm-FreeGestationGoalsHealthHigh Fat DietHumanHypothalamic structureHypothalamusImmuneImmune Cell ActivationImmunesImpairmentIndividualIndustrializationInfantile AutismInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInherited PredispositionInherited SusceptibilityInitiation FactorsInterdisciplinary ResearchInterdisciplinary StudyInterventionKanner's SyndromeLifeMediatingMetabolic syndromeMetagenomicsMiceMice MammalsModern ManMultidisciplinary CollaborationMultidisciplinary ResearchMurineMusNeural DevelopmentNeurodevelopmental DeficitNeurodevelopmental DisorderNeurological Development DisorderOutcomePathologicPathologyPathway interactionsPeptide Initiation FactorsPersonal SatisfactionPhenotypePhysiologyPhysiopathologyPopulationPredispositionPregnancyProbioticsProcessRNA SeqRNA sequencingRNAseqRag1Rag1 MouseRecoveryReportingRewardsSchizophreniaSchizophrenic DisordersSerumShort-Chain Fatty AcidsSocial BehaviorSocial InteractionSusceptibilitySynaptic plasticityT4 CellsT4 LymphocytesTestingTherapeuticTranslation Initiation FactorTranslational Initiation FactorVolatile Fatty AcidsWhole-Genome Shotgun SequencingWorkantenatal careassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingassociated symptomautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavioral assessmentcell sortingcell typechronic disorderco-morbid symptomco-occuring symptomcomorbid symptomcomparing females and malescomparing women and menconcurrent symptomcooccuring symptomcritical periodcytokinedementia praecoxdevelopmentaldietsdigestive tract microbiomediscrete timedysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiomeenteric microbiotaenvironmental riskepigeneticallyexperienceexposed in uterofecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfetalfetal exposurefetal programminggastrointestinal microbial floragastrointestinal microbiomegastrointestinal symptomgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedgut communitygut dysbiosisgut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehypothalamicimmune activationimmune functionimprintimprovedin uteroin utero exposureinflammation in mothersinflammatory disease of the intestineinflammatory disorder of the intestineinsightintestinal autoinflammationintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintra-uterine environmental exposureintrauterine environmental exposureliability to diseasemalematernal GI tractmaternal gutmaternal inflammationmaternal microbiomemetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmicrobialmicrobial imbalancemicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrobiome transplantmicrobiome transplantationmicrobiota transplantmicrobiota transplantationmother inflammationmother's gutneural circuitneural circuitryneural inflammationneurobehavioralneurocircuitryneurodevelopmentneurodevelopmental diseaseneuroinflammationneuroinflammatoryneuropathologicneuropathologicalneuropathologyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatryoffspringpathophysiologypathwaypatient populationprenatal exposureprenatally exposedpreventpreventingschizophrenicsexsex dimorphismsexual dimorphismsexually dimorphicsocialsocial defectssocial deficitssocial disorderssocial dysfunctionsociobehaviorsociobehavioralsymptom associationsymptom comorbiditysynaptic circuitsynaptic circuitrytherapeutic targettranscriptome sequencingtranscriptomic sequencingwell-beingwellbeingwomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
Project Summary
Social interaction is fundamental to the most universal of human experiences, such as family life, business, and
romance; however, social dysfunction is a debilitating hallmark of major neurodevelopmental disorders, including
autism and schizophrenia. Despite significant advances, the mechanisms underlying social dysfunction and…
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