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MATCHMAKERS - Solving T-cell receptor recognition and design via integrated high-throughput screening and structural, functional and computational approaches
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AI basedAddressAlgorithmsAntigen PresentationAntigen TargetingAntigenic DeterminantsAntigensBindingBinding DeterminantsBiochemicalCancer TreatmentCancersComplexComputer ModelsComputerized ModelsComputing MethodologiesDNA mutationDataData SetDevelopmentDrugsEducational process of instructingEngineeringEpitopesEventFaceFeedbackGenerationsGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationGerm LinesGoalsGrantHerpesviridaeHerpesvirusesHigh Throughput AssayHumanImmune PrecipitationImmune mediated therapyImmune responseImmune systemImmunityImmunologically Directed TherapyImmunologyImmunoprecipitationImmunotherapyIncrease lifespanInstitutionInvestigatorsLibrariesLigandsLytotoxicityMHC ReceptorMachine LearningMajor Histocompatibility Complex ReceptorMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicationMelanomaModelingModern ManMolecularMolecular InteractionMutationPeptide LibraryPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPharmaceutical PreparationsPulmonary CancerPulmonary malignant NeoplasmRecurrent Malignant NeoplasmRecurrent Malignant TumorResearch PersonnelResearchersSightSourceSpecificityStructureSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT memory cellT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor SpecificityT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-CellsT-LymphocyteT-cell receptor repertoireT-cell therapeuticsT-cell transfer therapyTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTCR repertoireTeachingTestingTherapeuticToxic effectToxicitiesTrainingTumor AntigensTumor-Associated AntigenUncertaintyVariantVariationVisionWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyalgorithm developmentanti-cancer therapyantigen-specific T cellsartificial intelligence basedboost longevitycancer antigenscancer recurrencecancer therapycancer typecancer-directed therapycheck point blockadecheckpoint blockadecohortcombinatorialcomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputing methodcytotoxicitydata to traindataset to traindesigndesigningdevelopmentaldoubtdrug/agentelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityfacesfacialfoster longevitygenome mutationherpes virushigh throughput screeninghost responseimmune check point blockadeimmune checkpoint blockadeimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoresponseimprove lifespanimprove longevityimprovedinsightintervention designlarge scale datalarge scale data setslarge scale datasetslifespan extensionlung cancermachine based learningmalignancymemory T lymphocytemethod developmentmouse modelmurine modelneoplasm/cancernew drug classnext generationnovel drug classpMHCpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprolong lifespanprolong longevitypromote lifespanpromote longevityquantumreconstitutereconstitutionresponsestructural biologysupport longevitysynthetic biologytherapeutic T-cell platformtherapy designthymus derived lymphocytetraining datatreatment designtumortumor-specific antigenvisual function
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Description preview
ABSTRACT: UCSF
Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully
understand how the immune system recognizes tumor antigens, and to reap the full potential of antigen-specific
immunotherapy. To achieve this goal, a quantum leap forward is required in which the revolutionary advances in
machine…
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