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MATCHMAKERS - Creating and training AI tools for TCR binding prediction and design
Organization MASSACHUSETTS INSTITUTE OF TECHNOLOGYLocation CAMBRIDGE, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AI basedAI model trainingAI trainingAddressAlanineAlgorithmsAntigen PresentationAntigen TargetingAntigensArtificial intelligence model trainingBase SequenceBenchmarkingBest Practice AnalysisBiochemicalBiologyCancer TreatmentCancersCollectionComplexComputer ModelsComputerized ModelsComputing MethodologiesDNA mutationDataData CollectionData SetDevelopmentDrugsEngineeringEventFaceFeedbackGenerationsGenetic ChangeGenetic defectGenetic mutationGoalsGrantHealth CareHumanImmune mediated therapyImmune responseImmune systemImmunityImmunodominant AntigensImmunologically Directed TherapyImmunologyImmunotherapyIncrease lifespanInstitutionInvestigatorsLibrariesLytotoxicityMHC ReceptorMachine LearningMajor Histocompatibility Complex ReceptorMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMedicationMelanomaMethodsModelingModern ManMolecularMutationNucleotide SequencePeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPharmaceutical PreparationsPhysicsProxyPulmonary CancerPulmonary malignant NeoplasmResearch PersonnelResearchersResolutionScanningSightSingle cell seqSourceSpecificityStructural ModelsStructureSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor InteractionT-Cell Receptor SpecificityT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-CellsT-LymphocyteT-cell receptor repertoireT-cell therapeuticsT-cell transfer therapyTCR ActivationTCR InteractionTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTCR repertoireTestingTherapeuticToxic effectToxicitiesTrainingTumor AntigensTumor-Associated AntigenUncertaintyValidationVirusVisionWorkYeastsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyalgorithm developmentalgorithm traininganti-cancer therapyartificial intelligence basedartificial intelligence trainingbenchmarkboost longevitycancer antigenscancer therapycancer typecancer-directed therapycheck point blockadecheckpoint blockadecombinatorialcomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer based predictioncomputer methodscomputerized modelingcomputing methodcross reactivitycytotoxicitydata to traindataset to traindesigndesigningdevelopmentaldoubtdrug/agentelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityfacesfacialfoster longevitygenome mutationhost responseimmune check point blockadeimmune checkpoint blockadeimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoresponseimprove lifespanimprove longevityimprovedinsightintervention designlarge scale datalarge scale data setslarge scale datasetslifespan extensionlung cancermachine based learningmalignancymethod developmentmouse modelmurine modelneoplasm/cancernew drug classnext generationnovel drug classnucleic acid sequencepMHCpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprediction algorithmpredictive modelingprolong lifespanprolong longevitypromote lifespanpromote longevityquantumreceptor bindingreceptor boundresolutionsresponsesingle cell next generation sequencingsingle cell sequencingstructural biologysupport longevitytherapeutic T-cell platformtherapy designthymus derived lymphocytetooltraining datatreatment designtumortumor-specific antigenvalidationsvisual function
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Description preview
Abstract
Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully
understand how the immune system recognizes tumor antigens, and to reap the full potential of antigen-specific
immunotherapy. To achieve this goal, a quantum leap forward is required in which the revolutionary advances in
machine learning…
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