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MATCHMAKERS
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureAI basedAddressAffinityAlgorithmsAllelesAllelomorphsAntibodiesAntigen PresentationAntigen TargetingAntigen-Antibody ComplexAntigensBenchmarkingBest Practice AnalysisBindingBiochemicalCancer TreatmentCancersCodeCoding SystemComplexComputer ModelsComputerized ModelsComputing MethodologiesDataData SetDevelopmentDrugsEngineeringEventFDA approvedFaceFeedbackGenerationsGenetics-MutagenesisGoalsGrantHumanImmune ComplexImmune mediated therapyImmune responseImmune systemImmunityImmunologically Directed TherapyImmunologyImmunotherapyIncrease lifespanIndividualInstitutionInvestigatorsLibrariesLinkLytotoxicityMHC ReceptorMachine LearningMajor Histocompatibility Complex ReceptorMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMeasuresMedicationMelanomaMethodsModelingModern ManMolecularMolecular InteractionMutagenesisMutagenesis Molecular BiologyOutputPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPharmaceutical PreparationsProbabilityProtein EngineeringProteinsPulmonary CancerPulmonary malignant NeoplasmReagentResearch PersonnelResearchersRestSightSiteSourceSpecificityStructureSystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor SpecificityT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-CellsT-LymphocyteT-cell diversityT-cell receptor repertoireT-cell therapeuticsT-cell transfer therapyTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTCR repertoireTestingTherapeuticToxic effectToxicitiesTrainingTumor AntigensTumor-Associated AntigenUncertaintyUniversitiesVisionWashingtonWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyalgorithm developmentanti-cancer therapyartificial intelligence basedatomic databenchmarkboost longevitycancer antigenscancer therapycancer typecancer-directed therapycheck point blockadecheckpoint blockadecombinatorialcomputational methodologycomputational methodscomputational modelingcomputational modelscomputer based methodcomputer based modelscomputer methodscomputerized modelingcomputing methodcytotoxicitydata to traindataset to traindesigndesigningdevelopmentaldoubtdrug/agentelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityfacesfacialfoster longevitygenetic protein engineeringhost responseimmune check point blockadeimmune checkpoint blockadeimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoresponseimprove lifespanimprove longevityimprovedinsightinterestintervention designlarge data setslarge datasetslarge scale datalarge scale data setslarge scale datasetslifespan extensionlung cancermachine based learningmalignancymethod developmentmonomermouse modelmurine modelneoplasm/cancernew drug classnext generationnovel drug classpMHCpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprolong lifespanprolong longevitypromote lifespanpromote longevityprotein complexprotein designquantumreceptor bindingreceptor boundresponsestructural biologysupport longevitytherapeutic T-cell platformtherapy designthree dimensional structurethymus derived lymphocytetraining datatreatment designtumortumor-specific antigenvisual function
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Description preview
Abstract
Understanding how T cell receptors (TCRs) see tumor antigens presented by MHCs is necessary to fully
understand how the immune system recognizes tumor antigens, and to reap the full potential of antigen-specific
immunotherapy. To achieve this goal, a quantum leap forward is required in which the revolutionary advances in
machine learning…
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