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Mast cell regulation of food allergen induced malaise through GDF15-GFRAL signaling
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Jan 2023Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025Abdominal PainAcuteAffinityAlimentary CanalAllergensAllergicAllergic inflammationAllergic to foodAllergy to foodAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAnorexiaAntibodiesAntigensArea PostremaAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasic ResearchBasic ScienceBasophilic GranulocyteBasophilsBehaviorBehavioralBehavioral ParadigmBindingBlocking AntibodiesBlood BasophilBlood SerumBody TissuesBody Weight decreasedBone-Derived Transforming Growth FactorCDDPCapsaicinCell BodyCell Communication and SignalingCell Culture SystemCell SignalingCellsCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClinicalClinical ResearchClinical StudyColonConditioned Taste AversionCysplatynaDNA Molecular BiologyDataDevelopmentDiarrheaDichlorodiammineplatinumDigestive DiseasesDigestive System DiseasesDigestive System DisordersDigestive TractDimethylbiguanidineDimethylguanylguanidineDiseaseDisease remissionDisorderEatingEconomic BurdenEffectivenessEmesisEndowmentEpithelial CellsEpitheliumFoodFood AllergyFood HypersensitivityFood IntakeGDF15GDF15 geneGI TractGI tract disorderGastrointestinal TractGastrointestinal tract structureGeneticHistamineHumanIgEIgG1ImmuneImmune memoryImmune responseImmunesImmunoglobulin EImmunologic MemoryImmunological MemoryIn VitroIncidenceIndividualInflammationInflammatoryIntestinalIntestinesIntracellular Communication and SignalingIrritable Bowel SyndromeIrritable ColonItchingKO miceKnock-out MiceKnockout MiceKnowledgeLeadLeukotrienesMIC-1 gene productMIC1Macrophage Inhibitory Cytokine-1MalaiseMarrow Mast CellMediatingMediatorMetforminMiceMice MammalsMilk Growth FactorModelingModern ManMolecular BiologyMolecular InteractionMucous ColitisMurineMusN,N-dimethyl-imidodicarbonimidic diamideNAG-1 proteinNAG1NSAID activated gene-1 productNSAID-Activated Protein 1NSAID-Regulated Protein 1NauseaNausea and VomitingNerveNerve CellsNerve UnitNeural CellNeurocyteNeuronsNociceptorsNonsteroidal Anti-Inflammatory Drug-Activated Protein 1Nucleus Tractus SolitariiNucleus solitariusNull MousePLABPLAB ProteinPTGF-BetaPathogenesisPathway interactionsPatientsPb elementPeyrone's ChloridePeyrone's SaltPhysiciansPlacental Bone Morphogenic ProteinPlacental TGF-BetaPlatelet Transforming Growth FactorPlatinum DiamminodichloridePlayPredispositionPrevalenceProductionProstate Differentiation FactorProteinsPruritic DisorderPruritisPruritusReceptor ProteinRegulationRemissionResearchRoleScientistSerumShrewsSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSolitary NucleusStressStructure of area postremaSusceptibilitySymptomsT-CellsT-LymphocyteTGF BTGF-betaTGF-βTGFbetaTGFβTaste aversionTechnical ExpertiseTestingTh-2 CellTh2 CellsTissue BasophilsTissuesTrainingTranscriptTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceType 2 Helper CellVascular PermeabilitiesVasodilatationVasodilationVasorelaxationVomitingWeight LossWeight ReductionWorkalimentary tractanamnestic reactionavoidance behaviorbehavior testbehavioral testbiological signal transductionbody weight lossbowelcareercell mediated immune responsechemotherapycis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumclinical relevanceclinically relevantcolonic cryptcomputer programcomputer programmingcytokinedesensitizationdevelopmentaldigestive canaldigestive disorderdigestive tract diseasedrivingfood allergenfood antigengastrointestinalgastrointestinal tract diseasegastrointestinal tract disorderglobal gene expressionglobal transcription profilegrowth differentiation factor 15heavy metal Pbheavy metal leadhost responseimmune system responseimmunogenimmunoresponsein vivoinhibitoritch sensationmast cellmastocytemouse modelmurine modelneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnociceptive neuronsnon-human primatenonhuman primatenovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoral immunotherapypain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspathwaypharmacologicpre-clinical studypreclinical studypreferencepreventpreventingprogramsreceptorresponsesecondary immune responseskillssmall bowelsocial rolesolitary tract nucleusspastic colontechnical skillsthymus derived lymphocytetranscriptometranscriptomicswt-loss
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Description preview
Food allergy is associated with a hypersensitive type 2 immune response that develops following
sensitization to food proteins. Allergic sensitization elicits the development of adaptive immune memory,
characterized by antigen specific Th2 cells and B-cells which produce antibodies of the IgE and IgG1 isotypes.
IgE antibodies bind to tissue…
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