grant
Maryland Prostate Cancer Case-Control Study
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years oldActive Follow-upAffectAfricanAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAgeAmericanAmerican maleAmerican manAmerican menAreaAwardBaltimoreBeadChipBiologicalBloodBlood Reticuloendothelial SystemBody TissuesCancer PatientCaribbean IslandsCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCessation of lifeChildChild YouthChildren (0-21)ChronicCitiesClassificationCollectionControl GroupsDNA MethylationDataData BasesDatabasesDeathDevelopmentDiabetes MellitusDiagnosisDietDietary FactorsDiseaseDisease MarkerDisease OutcomeDisease ProgressionDisorderDrugsEnrollmentEnvironmentEnvironmental FactorEnvironmental Risk FactorEuropeanEuropean ancestryExpression SignatureFamiliar Malignant NeoplasmFemaleFreezingFrequenciesGene ExpressionGene Expression ProfileGene variantGene x Environment InteractionGeneticGenetic predisposing factorGenotypeGerm LinesGhanaGleason GradeGleason Grade for Prostate CancerGleason ScoreGleason Score for Prostate CancerGleason SumGleason-SCGoalsGold CoastGuidelinesGxE interactionHereditary CancerHereditary Malignant NeoplasmHistoryHospitalsHouseholdHousehold HeadsImmuneImmune responseImmunesImpoverishedIndividualInfectionInflammationLinkMalignant neoplasm of prostateMalignant prostatic tumorMarylandMeasuresMedicalMedical HistoryMedical RecordsMedical centerMedicationMinorMolecularMolecular FingerprintingMolecular ProfilingMotor VehiclesMutation SpectraNCCNNational Comprehensive Cancer NetworkNative American AncestryNative American genetic ancestryNeighborhoodsNigerianOccupationalOperative ProceduresOperative Surgical ProceduresOutcomePSA levelPSA valueParaffin EmbeddingParticipantPathologicPathologyPathway interactionsPatientsPatternPenetrancePersonal Medical HistoryPersonal Medical History EpidemiologyPharmaceutical PreparationsPhasePilot ProjectsPovertyPredisposition geneProceduresProstate CAProstate CancerProstate NeoplasmsProstate TumorProstate malignancyProstatectomyProstatic NeoplasiaProstatic NeoplasmsProtocolProtocols documentationPublic AssistanceRaceRacesRecording of previous eventsRecordsRecurrent diseaseRelapsed DiseaseReportingResearchResearch ResourcesResearch SpecimenResourcesRiskRisk FactorsRoleSecureSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionSocio-economic statusSocioeconomic StatusSpecimenStressStudy SubjectSurgicalSurgical InterventionsSurgical ProcedureSurrogate MarkersSurvey InstrumentSurveysSusceptibility GeneSystematicsTM-MKRTNMTNM staging systemTimeTissue SampleTissuesTobacco ConsumptionTobacco useTobagoTumor BiologyTumor MarkersU.S. MalesUS MenUS maleUnemploymentUnited States Department of Veterans AffairsUnited States Veterans AdministrationUniversitiesUpdateUrineVenereal DiseasesVenereal DisordersVenereal InfectionsVeterans AdministrationVeterans AffairsViral DiseasesVirus DiseasesWest AfricanWest IndiesWorkactive followupadvanced diseaseadvanced illnessagesallelic variantallostatic loadbead chipbiologiccancer disparitycancer health disparitycancer-related health disparitycase-controlled studiescirculating biomarkerscirculating markerscohortcookingdata basedatabase of Genotypes and PhenotypesdbGaPdeprivationdesigndesigningdevelopmentaldiabetesdietsdifferences due to racedifferences in racediffers by racediffers in racedisease diagnosisdisease riskdisorder riskdisparity in cancerdrug/agentenrollenvironment effect on geneenvironmental riskethnic differenceethnicity differencefamilial cancerfollow upfollow-upfollowed upfollowupgene environment interactiongene expression patterngene expression signaturegene signaturesgenetic risk factorgenetic signaturegenetic variantgenomic varianthigh riskhistorieshost responseimmune system responseimmunoresponseindexinginflammation markerinflammatory markerinherited factorjoblessjoblessnesskidsmalemales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmenmen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesmetabolomemetabonomemolecular profilemolecular signaturemortalityout of workpathwaypilot studypopulation basedprecision medicineprecision-based medicinepredisposing geneprospectiveprostate cancer riskprostate specific antigen levelprostate specific antigen valuerace based differencesrace differencesrace related differencesracialracial backgroundracial differenceracial originracially differentrecruitsexually acquired infectionsmoking exposuresocial rolesocio-economic positionsocioeconomic positionsurgerysurrogate bio-markerssurrogate biomarkerssurvival disparitysusceptibility allelesusceptibility locussusceptibility variantsystemic inflammationsystemic inflammatory responsetobacco product usetranscriptional profiletranscriptional signaturetumortumor biomarkertumor specific biomarkerunemployedviral infectionvirus infectionvirus-induced diseaseyoungster♀♂
Description preview
Our study was implemented in two phases. The first phase, which started in April of 2005, constituted a pilot study to evaluate recruitment procedures. This phase was successful, and the full study was initiated with minor changes to the protocol in April of 2006. The full study was completed in 2015 [976 cases (489 African American and 487…
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