grant
Mapping the Epigenomic and Spatial Transcriptomic Landscape in Parkinson's Disease
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 20 Jan 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAD and related dementiaAD dementiaAD related dementiaADRDATACAddressAdult-Onset Diabetes MellitusAffectAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAssayAtlasesAttentionAutomobile DrivingAutopsyAβBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBiologyBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain regionCell BodyCell CommunicationCell InteractionCell NucleusCell to Cell Communication and SignalingCell-Cell SignalingCell-to-Cell InteractionCellsChromatin StructureChromiumChronicClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionCommunicationCommunitiesCooperative AgreementsCr elementCustomDA NeuronDataData SetDegenerative Neurologic DisordersDementiaDiseaseDisease ProgressionDisorderDissectionDisturbance in cognitionDopamine neuronDorsal Motor Nucleus of the VagusDysfunctionEncephalonEncephalon DiseasesEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsFunctional disorderGWA studyGWASGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGene variantGeneral TaxonomyGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic RiskGenetic TranscriptionGenomeGenomicsGlobus PallidusGoalsGrantGranular LayerGyrus HippocampiGyrus ParahippocampalisHeritabilityHippocampal GyrusHortega cellImpaired cognitionImpairmentIndividualInfrastructureIntracranial CNS DisordersIntracranial Central Nervous System DisordersKetosis-Resistant Diabetes MellitusKnowledgeLPTNLewy BodiesLigandsLinkMT-bound tauMapsMaturity-Onset Diabetes MellitusMeasuresMetabolicMicrogliaModelingMolecularMorphologyNAC precursorNIDDMNerveNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeuroendocrineNeuroendocrine SystemNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNeurosecretory SystemsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNucleusOrganPARK1 proteinPARK4 proteinPancreasPancreaticParahippocampal GyrusParalysis AgitansParkinsonParkinson DiseasePathogenesisPathologicPathologyPatientsPeripheralPhysiopathologyPositionPositioning AttributePrefrontal CortexPrimary ParkinsonismPrimary Senile Degenerative DementiaPrimary visual cortexProcessProteinsProxyRNA ExpressionReceptor ProteinRegulatory ElementResearchResearch ResourcesResolutionResourcesRisk-associated variantSCM-1SCM-1aSCM1SCYC1SNCASNCA proteinSamplingShapesSingle-Nucleus SequencingSlow-Onset Diabetes MellitusStable Diabetes MellitusStagingStratum GranulosumStriate CortexStriate areaSubstantia NigraSubstantia nigra structureSystemT2 DMT2DT2DMTau forming aggregatesTaxonomyTechniquesTechnologyTissuesTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesU-Series Cooperative AgreementsWorkXCL1XCL1 genea beta peptidea-syna-synucleinabetaabnormally aggregated tau proteinadult onset diabetesaggregation in tauallelic variantalpha synucleinalpha synuclein genealphaSP22amyloid betaamyloid-b proteinarea striataasynbeta amyloid fibrilcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell typecellular pathologycognitive dysfunctioncognitive losscohort investigationcohort researchcomparativecustomsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdifferential expressiondifferentially expresseddopaminergic neurondorsal motor nucleusdrivingentire genomeepigeneticallyepigenomeepigenomicsfilamentous tau inclusionfull genomegene regulatory networkgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic variantgitter cellglobal gene expressionglobal transcription profileimprovedintercellular communicationinvestigate cohortketosis resistant diabetesmaturity onset diabetesmesogliamicroglial cellmicrogliocytemicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumolecular biomarkermolecular markermolecular pathologymotor diseasemotor disordermotor dysfunctionmulti-modalitymultimodalitymultiomicsmultiple omicsnecropsynetwork modelsneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuronal degenerationneuropathologicneuropathologicalneuropathologyneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatric symptomnon A-beta component of AD amyloidnon A4 component of amyloid precursornon-geneticnongeneticpaired helical filament of taupallidumpanomicspathophysiologyperivascular glial cellpostmortemprimary degenerative dementiaprogramsreceptorresolutionsresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsNuc-Seqself-aggregate tausenile dementia of the Alzheimer typesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsoluble amyloid precursor proteinspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial relationshipspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicsstudy cohortsurvey cohorttangletautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau factortau fibrillationtau fibrillizationtau filamenttau inclusiontau neurofibrillary tangletau oligomertau paired helical filamenttau polymerizationtau protein accumulationtau protein aggregationtau-tau interactionthree dimensionaltranscription factortranscriptional differencestranscriptometranscriptomicstype 2 DMtype II DMtype two diabeteswhole genomewhole genome association analysiswhole genome association studyα synuclein geneα-synα-synucleinτ Proteinsτ aggregation
Description preview
Project Summary
Alzheimer’s disease (AD) and Alzheimer’s disease-related dementia (ADRD) and Parkinson’s disease (PD) are
chronic neurodegenerative disorders characterized clinically by cognitive impairment and neuropathologically
by abnormal protein accumulations (Aβ and α-Synuclein). Recent advances in understanding transcriptomic
changes in AD…
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