grant
Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAcademic achievementAchievementAchievement AttainmentAddressAdultAdult HumanAffectAgeAnxietyAttentionAutomobile DrivingBehaviorBeta CellBiochemicalBiologicalBiometricsBiometryBiostatisticsBrainBrain Nervous SystemBrittle Diabetes MellitusCaringCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChildChild CareChild YouthChildhoodChildren (0-21)ClinicalClinical DataClinical ResearchClinical ServicesClinical StudyClinical TrialsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsComplexDataDefectDevelopmentDevelopmental DelayDevelopmental Delay DisordersDiabetes MellitusDiabetic AcidosisDiabetic KetoacidosisDiabetic KetosisDiagnosisDiagnosticDimensionsDisturbance in cognitionDysfunctionEarly InterventionEducationEducational aspectsEncephalonEndocrinologistEnsureEquilibriumExposure toFamilyFingerprintFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureHybridsHyperglycemiaHypoglycemiaIDDMIQ DeficitImageImpaired cognitionImpairmentIndividualInfrastructureInsulin CellInsulin ResistanceInsulin Secreting CellInsulin-Dependent Diabetes MellitusIntermediary MetabolismInterventionIntervention StudiesJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLanguageLearningLinkLongitudinal StudiesMapsMeasuresMemoryMental DepressionMental HealthMental HygieneMetabolicMetabolic ProcessesMetabolismModelingNerve CellsNerve UnitNeural CellNeurocognitionNeurocognitiveNeurocognitive DeficitNeurocyteNeuronsNewly DiagnosedNorth CarolinaObservation researchObservation studyObservational StudyObservational researchOutcomeOutcome MeasurePathogenesisPhysiopathologyPlayPopulation HeterogeneityPrepuberal statePsychological HealthPsychosocial StressPuericultureQuestionnairesRaceRacesResearch InfrastructureResidualResidual stateRiskRisk FactorsRoleSeveritiesSiteSocial Support SystemSpecific Child Development DisordersStructureSubcellular ProcessSudden-Onset Diabetes MellitusSupport SystemSymptomsSystemT1 DMT1 diabetesT1DT1DMTechnologyTestingTherapeutic StudiesTherapy ResearchTimeType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVascular DiseasesVascular DisorderYouthYouth 10-21access to health careaccessibility of health careaccessibility to health careadulthoodadverse childhood eventsadverse childhood experiencesage associated effectsage effectage related effectsagesaging effectbalancebalance functionbiologicblood vessel disordercare giver stresscaregiver distresscaregiver stressclinical careclinical centerclinical research siteclinical sitecognitive developmentcognitive disabilitycognitive dysfunctioncognitive functioncognitive losscognitively disabledcomputer based predictiondepressiondevelopmentaldiabetesdiabetes educationdiabetic ketoacidoticdissemination strategydiverse populationsdrivingearly childhoodevidence baseexecutive controlexecutive functionfMRIhealth care accesshealth care availabilityhealth care servicehealth care service accesshealth care service availabilityheterogeneous populationhigh riskhyperglycemichypoglycemichypoglycemic episodesimagingimpact of ageinfluence of ageinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin toleranceintelligence quotient deficitintervention researchinterventional researchinterventional studyinterventions researchjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidslong-term studylongitudinal outcome studieslow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmeasurable outcomemulti-modalitymultidisciplinarymultimodalityneural imagingneuro-imagingneurocognitive declineneurocognitive impairmentneuroimagingneurological imagingneuronaloutcome measurementpathophysiologypatient populationpediatricpopulation diversitypredictive modelingprepubertalprepubertypreventpreventingprotective factorspsychosocialpsychosocial stressespsychosocial stressorsracialracial backgroundracial originrecruitresilienceresilience factorresiliency factorresilientresponseretention rateretention strategyrisk prediction algorithmrisk prediction modelrisk stratificationruralitysexsocial cognitionsocial health determinantssocial rolestratify riskstress among caregiverstress in caregiverstress on caregiverstressortechnology implementationtechnology validationtype I diabetestype one diabetesvascular dysfunctionvasculopathyyoungsteryouth ageβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY
The pathophysiology of cognitive dysfunction in prepubertal children with Type 1 Diabetes
Mellitus (T1DM) is not understood. It is likely that hyperglycemia, hypoglycemia, vascular
disease, insulin resistance, and diabetic ketoacidosis (DKA) play important roles. However, the
absence of longitudinal studies in T1DM children and our…
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