grant
Mapping Neural Recovery: Visualizing Peripheral Nerve Regeneration and Brain Plasticity Post-Peripheral Nerve Injury
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AcuteAddressAffectAnimalsAxonBiochemicalBody TissuesBrainBrain Nervous SystemBrain regionCNS Nervous SystemCalciumCalcium Ion SignalingCalcium SignalingCell Communication and SignalingCell SignalingCellular MatrixCentral Nervous SystemCerebral cortexChronic PhaseCytoskeletal SystemCytoskeletonDataDenervationDistalE-stimElectric StimulationEncephalonEnvironmentEvaluationFeedbackGeneralized GrowthGoalsGrowthHindlimbImageImaging ProceduresImaging TechnicsImaging TechniquesImpairmentImplantIndividualInjuryIntracellular Communication and SignalingKnock-outKnockoutLeadMapsMeasuresMiceMice MammalsModelingMonitorMotorMurineMusMyelin SheathNatural regenerationNerveNerve CellsNerve DegenerationNerve Impulse TransmissionNerve RegenerationNerve TransmissionNerve UnitNervous SystemNeural CellNeuraxisNeurilemma CellNeurilemmal CellNeuro-regenerationNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuron DegenerationNeuronal TransmissionNeuronsNeuroregenerationPatternPb elementPeripheralPeripheral NervesPeripheral Nervous SystemPeripheral nerve injuryPersonsPhaseProcessPrognosisProliferatingRecoveryRecovery of FunctionRegenerationResearchResolutionRestRoleSchwann CellsSensorySignal TransductionSignal Transduction SystemsSignalingSpeedStructureSynaptic plasticityTechniquesTestingTherapeutic EffectTimeTissue GrowthTissuesTrainingVisualizationWallerian DegenerationWorkaxon regenerationaxon signalingaxon-glial signalingaxonal regenerationaxonal signalingbiological signal transductioncortex mappingcortical mapcortical mappingelectrostimulationfunctional lossfunctional recoveryglia signalingglial signalingheavy metal Pbheavy metal leadimage-based methodimagingimaging methodimaging modalityimprovedimproved outcomeinjuriesinjury and repairinjury responseintracellular skeletonmouse modelmurine modelnerve damagenerve injurynerve reconstructionnerve repairnerve signalingnerve transectionnervous system regenerationneuralneural degenerationneural injuryneural regenerationneural signalingneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationneuronal signalingneuroregenerativeneurotransmissionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoptic imagingoptical imagingoptogeneticsperipheral nerve crush injuriesperipheral nerve damageperipheral nerve regenerationregenerateregenerated nerveregenerativerepair modelresolutionsresponseresponse to injurysciatic nervesecondary degenerationsignal processingskillssocial roletranslational goaltranslational mission
Description preview
SUMMARY
Traumatic peripheral nerve injuries (PNI) lead to functional loss and incomplete recovery of peripheral nerve
function while also impacting the corresponding brain regions that receive, process, and send out signals to and
from the affected nerves. A prolonged duration of denervation due to PNI have adverse implications for both the…
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