grant
Mapping and targeting 3D regulatory elements in leukemia and lymphoma
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 13 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY20253-D3-D analysis3-D structure3-Dimensional3-dimensional analysis3-dimensional structure3D3D analysis3D structureAcute T Cell LeukemiaAcute T-Cell Lymphoblastic LeukemiaAcute T-Cell Lymphocytic LeukemiaAcute T-Lymphocytic LeukemiaArchitectureAutoregulationBasal Transcription FactorBasal transcription factor genesBiologicalCRISPRCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/Cas systemCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCancersCell BodyCellsChromatinClinicalClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats interferenceCodeCoding SystemDNADataDedicationsDeoxyribonucleic AcidDevelopmentDiseaseDisorderDrug TherapyDrugsElementsEmergenciesEmergency SituationEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEssential GenesFunctional RNAGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic DiseasesGenetic TranscriptionGrantHDAC AgentHDAC inhibitorHeterogeneityHistone Deacetylase InhibitorHistone deacetylase inhibitionHomeostasisHumanImmune mediated therapyImmune systemImmunologically Directed TherapyImmunotherapyIntratumoral heterogeneityKnock-outKnockoutLaboratoriesMalignantMalignant - descriptorMalignant CellMalignant NeoplasmsMalignant TumorMapsMature T-CellMature T-LymphocyteMedicationMetabolic Protein DegradationModern ManModificationNoncoding RNANontranslated RNANuclearOutcomePatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPlayPrecursor T Lymphoblastic LeukemiaProtein TurnoverRNA ExpressionRNA SeqRNA sequencingRNAseqReactionRegulatory ElementRegulatory Protein DegradationResearch SpecimenRoleSamplingShapesSpecimenStressT cell differentiationT-Cell DevelopmentT-Cell LymphomaT-Cell NeoplasmT-Cell Non-Hodgkin's LymphomaT-Cell NonHodgkins LymphomaT-Cell OntogenyT-Cell SubsetsT-Cell Type Acute LeukemiaT-Cell and NK-Cell NeoplasmT-Cell and NK-Cell Non-Hodgkin's LymphomaT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-Lymphocyte SubsetsT-lineage acute lymphoblastic leukemiaTestingThree-dimensional analysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor CellUntranslated RNAWorkbiologiccancer cellcancer progressiondesigndesigningdevelopmentaldisease riskdisorder riskdrug interventiondrug treatmentdrug/agentepigeneticallyexperimentexperimental researchexperimental studyexperimentsgene networkgenetic conditiongenetic disorderheterogeneity in tumorsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyin silicointerestintra-tumoral heterogeneityintratumor heterogeneityleukemialeukemia/lymphomalong read seqlong-read sequencinglong-read transcript sequencinglymphoma/leukemiamalignancyneoplasm progressionneoplasm/cancerneoplasticneoplastic cellneoplastic progressionnon-geneticnoncodingnongeneticpeptide mimeticpeptide mimicpeptidomimeticspharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprogenitorprogramspromoterpromotorprotein degradationrepressing CRISPR-dCas9 systemresponseresponse to therapyresponse to treatmentscATAC sequencingscATAC-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle moleculesingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsmall moleculesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsethree dimensionalthree dimensional structurethymus derived lymphocytetooltranscription factortranscriptome sequencingtranscriptomic sequencingtreatment responsetreatment responsivenesstumor heterogeneitytumor progressiontumorigenic
Description preview
PROJECT SUMMARY/ABSTRACT
Despite cancer being typically depicted as a genetic disease, aberrations in epigenetics and gene expression
play a determinant role in transformation and response to therapies. Derailed from their developmental paths,
malignant cells may arrest their differentiation fate and activate alternative programs. Aberrant…
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