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Manipulation of the gut microbiome to delay breast cancer onset and progression in the context of weight loss and obesity
Organization UNIVERSITY OF TENNESSEE HEALTH SCI CTRLocation MEMPHIS, UNITED STATESPosted 28 May 2025Deadline 5 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025AccelerationAffectAmino AcidsAntibiotic AgentsAntibiotic DrugsAntibioticsAreaAutoregulationBacteriaBacteroidesBifidobacteriumBile AcidsBioinformaticsBody Weight decreasedBranched-Chain Amino AcidsBreast CancerBreast Cancer ModelBreast Cancer PatientBreast Cancer Risk FactorBreast Tumor PatientBreast tumor modelCancer BurdenCancersCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell-to-Cell InteractionCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessClostridiumCo-cultureCocultivationCocultureCoculture TechniquesComplementComplement ProteinsDataDiagnosisDigestionDiseaseDisorderER PositiveER+EndocrineEnergy ExpenditureEnergy MetabolismEstrogen receptor positiveFacultyFatty AcidsFunctional MetagenomicsGI commensalGI microbiomeGI microbiotaGall BladderGallbladderGallbladder / BiliarGallbladder/Biliary systemGastrointestinal microbiotaGoalsHistoryHomeostasisHumanImmuneImmune Cell ActivationImmune mediated therapyImmune signalingImmune systemImmunesImmunityImmunologically Directed TherapyImmunologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyIn VitroInstitutionInterventionIntestinalIntestinesIntracellular Communication and SignalingInvestigationInvestigatorsLactobacillusLarge IntestineLeannessLiteratureLiverMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMediatingMediatorMetagenomicsMethodsMiceMice MammalsMicrobeMicrobial GeneticsMicrobiologyMiscellaneous AntibioticModelingModern ManModificationMurineMusNK T cellNKT cellNational Cancer BurdenNatural Killer T cellObesityOrganoidsOutcomePD-L1 antibodyPatientsPhysiological HomeostasisPositionPositioning AttributePostdocPostdoctoral FellowPre-Clinical ModelPreclinical ModelsProductionPublishingRecording of previous eventsReportingResearchResearch AssociateResearch PersonnelResearchersRiskRoleSamplingScience of Microbial GeneticsSecondary toShapesShort-Chain Fatty AcidsSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessTNBCTechniquesTestingTherapeuticThinnessTrainingTumor BurdenTumor ImmunityTumor LoadTumor-infiltrating immune cellsVolatile Fatty AcidsWeight LossWeight ReductionWorkaPD-L1aPD-L1 antibodiesadiposityaminoacidanti programmed cell death ligand 1anti programmed cell death protein ligand 1anti-PD-(L)1anti-PD-L1anti-PD-L1 antibodiesanti-PD-L1 monoclonal antibodiesanti-PDL-1anti-PDL1anti-PDL1 antibodiesanti-tumor effectanti-tumor immune therapyanti-tumor immunityanti-tumor immunotherapyantiPD-L1antitumor effectantitumor immunitybariatric surgerybiological signal transductionbody weight lossbowelbranched amino acidsbreast cancer diagnosisbreast cancer progressionbreast cancer riskcancer immunitycancer microenvironmentcancer progressioncancer sub-typescancer subtypescommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecomplementationcorpulencedigestive tract microbiomedysbacteriosisdysbiosisdysbioticenteric commensalenteric microbial communityenteric microbiomeenteric microbiotaexperiencefecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal samplefecal transplantfecal transplantationgastric bandinggastric bypass surgerygastrointestinal commensalgastrointestinal microbial floragastrointestinal microbiomegenetic approachgenetic strategygut commensalgut communitygut dysbiosisgut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehepatic body systemhepatic organ systemhistoriesimmune activationimmune cell infiltration of tumorsimmune cells infiltrating the tumorimmune cells that infiltrate the tumorimmune functionimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimplantable gastric stimulation bandingimprovedimproved outcomein vivoin vivo Modelindividuals with breast cancerinfiltration of tumors by immune cellsinnovateinnovationinnovativeintestinal biomeintestinal commensalintestinal floraintestinal microbesintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintratumoral immune cellintratumoral immune infiltratelarge bowelmalignancymalignant breast tumormammary cancer modelmammary tumor modelmembermetabolism measurementmetabolomicsmetabonomicsmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremicrobiotamicrofloramicroorganism geneticsmouse modelmultispecies consortiamurine modelnatural killer T lymphocyteneoplasm immunotherapyneoplasm progressionneoplasm/cancerneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachobese patientsobesity surgerypatients with breast cancerpatients with obesityperson with breast cancerpost-docpost-doctoralpost-doctoral traineerecruitresearch associatesresponseresponse to therapyresponse to treatmentskillssocial rolestomach staplingstool samplestool specimentherapeutic responsetherapeutic targettherapy responsetraining opportunitytranscriptomicstreatment responsetreatment responsivenesstriple-negative breast cancertriple-negative invasive breast carcinomatumortumor immune celltumor immune infiltratetumor immune therapytumor immunotherapytumor infiltration of immune cellstumor microenvironmenttumor progressionweight loss surgerywt-lossαPD-L1αPD-L1 antibodiesαPDL1
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Description preview
Summary
Bariatric surgery is associated with reduced breast cancer (BC) risk, improved outcomes, and increased
immunotherapy efficacy, but mechanisms remain undefined. By examining the underlying mechanisms of
bariatric surgery-induced protection, novel therapeutic approaches may be identified to benefit both lean and
obese patients. Long-term…
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