grant
Manipulating alpha(v) integrins on B cells to promote lung-resident B cell responses
Organization SEATTLE CHILDREN'S HOSPITALLocation SEATTLE, UNITED STATESPosted 1 Aug 2020Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AddressAffinityAirway mucosaAntibodiesAntigensAreaB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiologyBlood Plasma CellBody TissuesCD19CD19 geneCD51 AntigensCell BodyCell Communication and SignalingCell Culture TechniquesCell Mediated ImmunologyCell SignalingCell-Mediated ImmunityCellsCellular ImmunityDataFamilyGenerationsGerminal CenterGrippeHealthHumanIg Somatic HypermutationIgAImmune responseImmunityImmunizationImmunoglobulin AImmunoglobulin Somatic HypermutationInfectionInfluenzaInfluenza VirusIntegrin alphaVIntegrin αVIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLigandsLower respiratory tract structureLungLung CapacityLung Respiratory SystemLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesMaintenanceMemoryMemory B CellMemory B-LymphocyteMiceMice MammalsModelingModern ManMucosaMucosal Immune ResponsesMucosal TissueMucous MembraneMurineMusMutateNull MouseOrganoidsPlasma CellsPlasmacytesProcessPulmonary Body SystemPulmonary Organ SystemReactionReceptor SignalingRespiratory MucosaRespiratory SystemRespiratory TractsRespiratory tract structureRoleSARS VirusSARS corona virusSARS coronavirusSARS-Associated CoronavirusSARS-CoVSARS-CoV-1SARS-Related CoronavirusSevere Acute Respiratory CoronavirusSevere Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSiteStructureStructure of germinal center of lymph nodeSystemTLR proteinTestingTherapeuticTissuesToll-Like Receptor Family GeneToll-like receptorsVaccinationVaccinesVariantVariationViralViral AntigensViral DiseasesVirusVirus DiseasesWorkalpha(V) Integrinantagonismantagonistbiological signal transductioncell culturecell culturescell mediated immune responsecross reactivitydesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedisease severityemergent pandemicemerging pandemicflu infectionflu virus infectionfunctional improvementhost responseimmune system responseimmunogenimmunoresponseimprove functionimprovedimproved functional outcomesinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioninfluenzavirusinnovateinnovationinnovativelower respiratory tractlymph glandlymph nodeslymphnodesnew pandemicnovel pandemicpandemicpandemic diseasepharmacologicplasmocyterespiratoryrespiratory virusresponserestraintscRNA sequencingscRNA-seqsevere acute respiratory syndrome-CoVsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesomatic hypermutationvaccine developmentviral infectionvirus antigenvirus infectionvirus-induced disease
Description preview
Project Summary/Abstract
Current vaccines against mucosal respiratory viruses, although effective at reducing disease severity, do not
provide protection at the respiratory tract, the site of infection, cannot effectively protect against multiple variants
of the viruses and do not induce long-lived immune response. Therefore, there is a need to…
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