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Maladaptive Remodeling of the Neuromuscular Synapse Following Central Nervous System Injury
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Mar 2023Deadline 31 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025AcuteAffectAgingApoplexyApplications GrantsAreaAxonBDNFBehavioralBrain InfarctionBrain Vascular AccidentBrain-Derived Neurotrophic FactorCNS InjuryCNS Nervous SystemCausalityCell Communication and SignalingCell SignalingCentral Nervous SystemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicChronic disabilityClinicalClinical ResearchClinical StudyCommunicationConfocal MicroscopyDNA TherapyDataDevelopmentDiseaseDisorderDysfunctionElectrophysiologyElectrophysiology (science)EnvironmentEtiologyEventExhibitsFacultyFellowshipFosteringFunctional disorderFutureGene Transfer ClinicalGeneralized GrowthGenetic InterventionGrant ProposalsGrowthHealthHistologicHistologicallyHistopathologyHornsImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIntracellular Communication and SignalingInvestigationIschemiaIschemic StrokeLeannessLesionLinkLongitudinal StudiesMeasuresMediatingMediatorMentorsMentorshipMethodologyMolecularMolecular Biology TechniquesMorphologyMotorMotor CellMotor NeuronsMotor outputMuscleMuscle FibersMuscle ParesisMuscle TissueMuscle functionMuscular ParesisMyoneural JunctionMyotubesNerve CellsNerve DegenerationNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeuraxisNeuro rehabilitationNeurocyteNeurologicNeurologicalNeurological DamageNeurological InjuryNeurological traumaNeuromuscular DiseasesNeuromuscular JunctionNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyNeurorehabilitationOhioPNS DiseasesPalsyParalysedParesisPeripheralPeripheral Nerve DiseasesPeripheral Nervous SystemPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPersistent disabilityPersonsPhysiciansPhysiologyPhysiopathologyPlegiaPositionPositioning AttributePrevalenceQuadriplegiaQuadriplegicRecoveryRecovery of FunctionReportingResearchResearch ResourcesResourcesRhabdomyocyteRoleSCI PatientsScientistSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSpecialistSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injurySpinal cord injury patientsStrokeSynapsesSynapticTestingTetraplegiaTherapeuticThinnessTissue BanksTissue CollectionTissue GrowthTissue repositoryTrainingTrans-Synaptic DegenerationTransmissionTransneuronal Retrograde DegenerationsTraumatic MyelopathyUniversitiesViralVoluntary MuscleWorkafter strokebiological signal transductionbrain attackbrain infarctcareercareer developmentcausationcentral nervous system injurycerebral vascular accidentcerebrovascular accidentclinical relevanceclinically relevantcombatdevelopmentaldisabilitydisability burdendisease causationelectrophysiologicalexperiencefunctional recoverygene repair therapygene therapygene-based therapygenetic therapygenomic therapyglobal gene expressionglobal transcription profilehemiparesishemipareticin vivoinjured CNSinnervationlong-term studylongitudinal outcome studiesmotoneuronmotor behaviormotor controlmotor diseasemotor disordermotor dysfunctionmotor impairmentmouse modelmovement impairmentmovement limitationmurine modelmuscularmyoneural disordernerve supplyneural degenerationneurodegenerationneurodegenerativeneurological degenerationneurological rehabneurological rehabilitationneuromotor systemneuromuscularneuromuscular degenerative disorderneuromuscular disorderneuromuscular systemneuronalneuronal degenerationneurorehabneurorehabilitativeneurotraumanovelontogenyoverexpressoverexpressionparalysisparalyticpareticparetic musclepathophysiologypost strokepoststrokepre-clinicalpre-clinical studypreclinicalpreclinical studyrecruitresponsesocial rolestroke modelstroke survivorstrokedstrokessynapsetetraplegictherapeutic agent developmenttherapeutic developmenttherapeutic evaluationtherapeutic targettherapeutic testingtraining opportunitytranscriptometransmission processyears lived with disability
Applications closed.
Description preview
PROJECT SUMMARY / ABSTRACT
Central nervous system (CNS) injuries such as stroke and spinal cord injury (SCI) are major contributors to the
global burden of disability. Attenuating CNS damage represents the core of research and neurorehabilitation
strategies to enhance recovery. Yet, mounting evidence of peripheral nervous system (PNS) alterations…
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