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Magnetic resonance imaging methods to track Treg distribution and homing for clinical applications
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 11 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AccelerationAcuteBiodistributionBiological MarkersBloodBlood Reticuloendothelial SystemBody TissuesCD25CD34CD34 geneCardiac ToxicityCardiotoxicCardiotoxicityCell BodyCell Communication and SignalingCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell TherapyCellsChronicClinicalClinical ResearchClinical StudyContrast AgentContrast DrugsContrast MediaDermatoplastiesDermatoplastyDevelopmentDevicesDiabetes MellitusDoseEvaluationFDA approvedFe oxideGeneralized GrowthGoalsGrafting ProcedureGrowthH+ elementHPCA1HomingHumanHydrogen IonsIL2RIL2RAIL2RA geneImageImaging DeviceImaging InstrumentImaging ToolImaging technologyImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIn VitroIncubatedInfusionInfusion proceduresIntracellular Communication and SignalingIntravenousLabelLegal patentLeukapheresisLeukocytapheresisLifeLiverMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant CellManufacturerMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMiceMice MammalsMicrobeadsMicrospheresMinorModelingModern ManMonitorMorbidityMorbidity - disease rateMurineMusNMR ImagingNMR TomographyNephrotoxicNuclear Magnetic Resonance ImagingOrgan TransplantationOrgan TransplantsOutcomePatentsPatientsPhenotypeProcessProgenitor CellsPropertyProtocolProtocols documentationProtonsPublishingQOLQuality of lifeRadiationRadiopaque MediaRegimenRegulatory T-LymphocyteRiskScientistSignal TransductionSignal Transduction SystemsSignalingSkin TransplantationSkin graftSolidSpleenSpleen Reticuloendothelial SystemT-CellsT-LymphocyteTCGFRTechniquesTechnologyTestingTherapeuticTherapeutic LeukopheresisTherapeutic UsesTimeTissue GrowthTissuesToxic effectToxicitiesTransfectionTranslatingTransplant RecipientsTransplantation SurgeryTransplantation ToleranceTreatment EfficacyTreatment ProtocolsTreatment RegimenTreatment ScheduleTregVisualizationWorkZeugmatographyallogenic skin graftallograft rejectionbench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebio-markersbiologic markerbiological signal transductionbiomarkercancer cellcell based interventioncell mediated interventioncell mediated therapiescell sortingcell typecell-based therapeuticcell-based therapycellular therapeuticcellular therapyclinical applicabilityclinical applicationclinical relevanceclinical translationclinically relevantclinically translatablecolcotharcytokinedevelop therapydevelopmentaldiabetesdisease modeldisorder modelend-stage organ failureexperienceferric oxidehepatic body systemhepatic organ systemimage guidanceimage guidedimage-based methodimagingimaging methodimaging modalityimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressed patientimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoindividual patientinfusionsintervention developmentintervention efficacyiron oxidekidney toxicitymouse modelmurine modelnephrotoxicitynovelontogenyorgan allograftorgan graftorgan transplant patientorgan transplant recipientorgan xenograftpreventpreventingred iron oxideregulatory T-cellsside effectstem cellstherapeutic efficacytherapeutically effectivetherapy developmenttherapy efficacythymus derived lymphocytetranslational opportunitiestranslational potentialtransplant patienttreatment development
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PROJECT SUMMARY
Solid organ transplantation (SOT) has transformed the survival and quality of life of patients with end-stage
organ failure. In 2019, 39,719 transplant surgeries were conducted in the US. However, allograft rejection
represents a significant cause of morbidity with an estimated 25-50% of transplant recipients experiencing some
of…
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