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Macrovascular and Microvascular Response to Fluid Removal during Hemodialysis for Acute Kidney Injury
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jul 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AbscissionAchievementAchievement AttainmentAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAdvanced DevelopmentAdverse effectsAffectAgeArteriesAttentionAwardBedside TestingsBlood PlasmaBlood Pressure MonitorsBlood VesselsBody TissuesCardiac OutputCerebrovascular CirculationCerebrumCessation of lifeChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalCohort StudiesComplexComplicationConcurrent StudiesContinuous SphygmomanometersCritical IllnessCritically IllDataData SetDeathDegree programDevelopmentDevelopment PlansDevicesDialysisDialysis procedureDiffuseDysfunctionESKDESRDEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesEpidemiologyEquilibriumExcisionExtirpationFluid overloadFunctional disorderFundingGoalsHctHematocritHematocrit procedureHemodialysesHemodialysisHospital AdmissionHospitalizationHybridsHypotensionImpairmentInpatientsInstitutionIntensive Care UnitsIntervention StudiesInvestigationInvestigatorsIschemiaKidneyKidney DiseasesKidney Replacement TherapyKidney Urinary SystemLifeLinear RegressionsLinkLiquid substanceLow Blood PressureMaintenanceMaster of ScienceMaster's DegreeMeasurementMeasuresMediatingMediationMediatorMentorsMethodologyMethodsMethods EpidemiologyMethods in epidemiologyModalityModelingMonitorMyocardial StunningNegotiatingNegotiationNephropathyO elementO2 elementObservation researchObservation studyObservational StudyObservational researchOperative ProceduresOperative Surgical ProceduresOpticsOrganOut-patientsOutcomeOutcome StudyOutpatientsOxygenPacked Erythrocyte VolumePacked Red-Cell VolumeParticipantPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPerfusionPersonalized medical approachPersonsPhysiologyPhysiopathologyPlasmaPlasma SerumPopulationPositionPositioning AttributePostoperativePostoperative PeriodPredispositionProbabilistic ModelsProbability ModelsProspective StudiesProspective cohortProspective, cohort studyReaction TimeRecoveryRemovalRenal DiseaseRenal Replacement TherapyRenal dialysisResearch DesignResearch PersonnelResearchersResponse RTResponse TimeReticuloendothelial System, Serum, PlasmaRiskSpectroscopySpectrum AnalysesSpectrum AnalysisStatistical ModelsStudy TypeStunned MyocardiumSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSusceptibilitySystemTechniquesTechnologyTestingTissuesTrail Making TestTrainingTreatment FactorUltrafiltrationVascular Hypotensive DisorderVenousWorkacute careacute kidney injuryadverse consequenceadverse outcomeagesanalyzing longitudinalbalancebalance functionblood flow in brainbrain blood circulationbrain blood flowbrain oxygenationcardiac functioncareer developmentcerebralcerebral autoregulationcerebral blood flowcerebral circulationcerebral oxygenationcerebrocirculationcerebrovascular blood flowchronic kidney diseaseclinical epidemiologyco-morbidco-morbiditycognitive assessmentcognitive functioncognitive testingcohortcomorbiditycontinuous monitoringdesigndesigningdevelopmentaldialysis therapyepidemiologicepidemiologicalexperiencefluidfunction of the heartheart functionheart outputhemodynamicshigh dimensional datahypervolemiahypoperfusionimprovedindividualized approachinterstitialintervention researchinterventional researchinterventional studyinterventions researchkidney dialysiskidney disorderliquidlongitudinal analysismultidimensional datamultidimensional datasetsmultidisciplinarymultimorbiditymultiple chronic conditionsnew approachesnovel approachesnovel strategiesnovel strategyopticalpathophysiologypatient oriented outcomespersonalized approachprecision approachpressurepreventpreventingprogramsprospectivepsychomotor reaction timerenalrenal disorderresectionresponseskillsspatial and temporalspatial temporalspatiotemporalstatistical linear mixed modelsstatistical linear modelsstudy designsurgerytailored approachtreatment effectvascularvigilance
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Description preview
Project Summary
Over 13 million people develop acute kidney injury (AKI) each year. AKI increases the risk of incident chronic
kidney disease, end-stage kidney disease, and death. Fluid removal (ultrafiltration) is an important component
of managing dialysis-requiring AKI (AKI-D), but safe achievement of optimal volume status involves a delicate…
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