grant
Macrophage-fibroblast interaction is required for asbestos-induced toxicity
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AccreditationAdverse effectsAffectAlveolar MacrophagesAntibodiesAsbestosAsbestosisAttenuatedAutoregulationBindingBioenergeticsBlood monocyteBody SystemBody TissuesCSF1CSF1 geneCancersCarnitineCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCessation of lifeChIP SequencingChIP-seqChIPseqCo-cultureCocultivationCocultureCoculture TechniquesCommunicationDataDeathDiseaseDisease OutcomeDisorderErinaceidaeExposure toFibroblastsFibrosisGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGenesGenus HippocampusGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneHeartHedgehog (Hh) signal transduction pathwayHedgehogsHomeostasisHumanIntermediary MetabolismIntracellular Communication and SignalingKidneyKidney Urinary SystemLiverLungLung Respiratory SystemLung Tissue FibrosisLung damageMCSFMGC31930MacrophageMacrophage ActivationMalignant NeoplasmsMalignant TumorMarrow monocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModern ManMolecularMolecular InteractionMurineMusMφOrganOrgan SystemOutcomePDGFPathway interactionsPhenotypePhysiological HomeostasisPlatelet-Derived Growth FactorProductionProteinsPulmonary FibrosisPulmonary MacrophagesRecombinantsRoleSHHSHH geneSeahorseSignal TransductionSignal Transduction SystemsSignalingSonic HedgehogSourceTechniquesTestingTissuesToxic effectToxicitiesTransgenic MiceUnited Statesaccreditedaerobic glycolysisattenuateattenuatesbiological signal transductioncell typechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcurative interventioncurative therapeuticcurative therapycurative treatmentsdruggable targetexposed human populationfatty acid oxidationfibrosis in the lungglioma associated oncogene 1glioma associated oncogene family zinc finger 1hedgehog signalinghedgehog signaling pathwayhepatic body systemhepatic organ systemhh signaling pathwayhuman exposurehuman subjecthuman tissueinhibitorinnovateinnovationinnovativeinsightlung fibrosislung injurymalignancymetabolic profilemitochondrialmonocyteneoplasm/cancerpathwaypharmacologicpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrenalresponsesmoothened signaling pathwaysocial roletherapeutic target
Description preview
All organ tissues contain fibroblasts and macrophages. Emerging evidence indicates that direct interaction
between fibroblasts and macrophages occur to maintain homeostasis as well as determining disease outcomes,
such as asbestos-induced toxicity. The interaction, or communication, between these cells have a role in
changing the phenotype of each…
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