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Lymphatics-Glymphatics in CNS Fluid Homeostasis
Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025ATP phosphohydrolaseATPaseAbscissionAccelerationAccessory SinusesAdenosine TriphosphataseAffectAngiotensin-Forming EnzymeAngiotensinogenaseAngiotensinsAnimal ModelAnimal Models and Related StudiesApneaArteriesAutoregulationBiochemicalBiophysicsBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain DrainsBrain MappingBrain Nervous SystemBreathingCNS Nervous SystemCNS lymphatic systemCPAPCPAP VentilationCalcium Ion SignalingCalcium SignalingCannulationsCarbonate hydro-lyaseCarbonic AnhydrasesCardiopulmonaryCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell SignalingCentral Nervous SystemCentral venous pressureCerebrospinal FluidCervicalCervical Lymph NodeCervical lymph node groupCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComputer AnalysisContinuous Positive Airway PressureCoupledCouplingDataDevice DesignsDiffusionDisturbance in cognitionDrainageDrainage procedureDysfunctionEncephalonExcisionExtirpationExtracellular ProteinFeedbackFluid BalanceFluid HomeostasisFunctional disorderGoalsH+ elementHealth BenefitHeart VascularHemato-Encephalic BarrierHomeostasisHydrogen IonsImageImpaired cognitionInflammationIntercellular FluidInterstitial FluidsIntracellular Communication and SignalingIntracranial PressureInvestigationIon TransportKnowledgeLaboratoriesLigatureLiquid substanceLymphLymph Node MappingLymph SystemLymphaticLymphatic NetworkLymphatic SystemLymphatic System Reticuloendothelial SystemLymphatic functionMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMeasurementMechanicsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedulla SpinalisMeningeal circuitMeningeal lymphatic networkMeningeal lymphatic pathwayMeningeal lymphatic systemMeningeal lymphaticsModalityMolecularMonitorMorphologyNMR ImagingNMR TomographyNasal Continuous Positive Airway PressureNasal SinusesNasal cavity/ParanasalNasal cavity/Paranasal sinusesNeuraxisNuclear Magnetic Resonance ImagingParanasal SinusesPathway interactionsPeptidesPhysiologicPhysiologic MonitoringPhysiologicalPhysiological HomeostasisPhysiological MonitoringPhysiopathologyPostureProductionProteinsProteomicsProtonsRefuse DisposalRelaxationRemovalReninRenin-Angiotensin SystemRespiratory AspirationRespiratory InspirationRodentRodentiaRodents MammalsRoleSeriesSignal TransductionSignal Transduction SystemsSignalingSinusSpinal CordStressSubarachnoid PressureSurgical RemovalSystemTechniquesTestingTherapeuticTidal VolumeVisualizationZeugmatographybiological signal transductionbiophysical analysisbiophysical foundationbiophysical principlesbiophysical sciencesbiophysical studiesbloodbrain barrierbrain controlbrain lymph systembrain lymphatic systemcarbonate dehydratasecerebral spinal fluidcirculatory systemclinical relevanceclinically relevantcognitive dysfunctioncognitive losscommon treatmentcomputational analysescomputational analysiscomputer analysesdiffuseddiffusesdiffusingdiffusionsexperimentexperimental researchexperimental studyexperimentsfluidglia lymphatic circuitglia-lymphatic systemglial lymphatic systemglialymphatic circuitglialymphatic networkglialymphatic pathwayglialymphatic systemglymphatic clearance pathwayglymphatic functionglymphatic pathwayglymphatic systemglymphatic-lymphatic systemglymphaticshemodynamicsimagingimaging in vivoin vivo imaginginnovateinnovationinnovativeinspirationlife spanlifespanliquidlymph channellymph flowlymph vessellymphatic channellymphatic drainagelymphatic flowlymphatic fluidlymphatic mappinglymphatic vesselmechanicmechanicalmodel of animalnCPAP Ventilationnovelparavascular systempathophysiologypathwaypreventpreventingprotein functionproteomic signatureresectionrespiratoryrespiratory airway volumeresponsesocial rolesolutespinal fluidstressorsystemic interventiontheoriesvoltagewaste disposalwasting
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Description preview
Summary
The glymphatic and lymphatic systems are essential for waste drainage and fluid homeostasis of the central
nervous system (CNS). It has therefore been hypothesized that therapeutic efforts to maintain or accelerate
glymphatic/lymphatic functions throughout the life-span would be beneficial for preventing cognitive dysfunction.…
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