grant
Lymphatic Endothelial Piezo1-TRPV4 Channel Signaling in Obesity
Organization LOUISIANA STATE UNIV HSC SHREVEPORTLocation SHREVEPORT, UNITED STATESPosted 14 Feb 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202621+ years oldAdipose tissueAdultAdult HumanAgonistAmericanApoplexyAwardBackBlood CirculationBlood VesselsBloodstreamBody TissuesBody WeightBody fatBrain Vascular AccidentCardiovascular DiseasesCationsCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronic DiseaseChronic IllnessDataDevelopmentDiabetes MellitusDorsumDysfunctionElectrophysiologyElectrophysiology (science)EnvironmentExtravasationFatty TissueFunctional disorderHandHealthHigh Fat DietHydrostatic PressureImageImpairmentInflammationIntercellular FluidInterstitial FluidsIntracellular Communication and SignalingInvestigatorsIon ChannelIonic ChannelsKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeakageLinkLiposomalLiposomesLoxP-flanked alleleLymphLymphangiogramLymphangiographyLymphaticLymphatic Endothelial CellsLymphatic EndotheliumLymphatic functionMeasurementMembrane ChannelsMentorsMesentericMesenteryMiceMice MammalsMurineMusMuscle CellsMyocytesNational Institutes of HealthNeurophysiology / ElectrophysiologyNull MouseObesityPathogenicityPathway interactionsPeripheralPermeabilityPhysiopathologyPiezo 1Piezo 1 ion channelPiezo1PostdocPostdoctoral FellowProtein AnalysisProteinsReceptor ProteinRegulationResearchResearch AssociateResearch PersonnelResearchersRisk FactorsRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpillageStrokeTamoxifenTestingTissuesTrainingUnited StatesUnited States National Institutes of HealthVanilloidWeightWeight GainWeight IncreaseWeight maintenance regimenadiposeadiposityadulthoodbiological signal transductionbody weight gainbody weight increasebrain attackcardiovascular disordercareer developmentcerebral vascular accidentcerebrovascular accidentchronic disordercorpulencecostdevelopmentaldiabeteselectrophysiologicalfeedingfloxedfloxed allelehandsimagingimprovedlymph channellymph vessellymphatic channellymphatic dysfunctionlymphatic fluidlymphatic impairmentlymphatic valvelymphatic vesselmortalitynovelpathophysiologypathwaypost-docpost-doctoralpost-doctoral traineepreventpreventingreceptorresearch associatesshear stresssocial rolestrokedstrokesvascularweight controlweight managementweightswhite adipose tissuewt gainyellow adipose tissue
Description preview
Obesity is a serious health concern in the US and is a significant risk factor for many causes of mortality, including
stroke and cardiovascular disease. Significant evidence points to an important pathogenic link between lymph
barrier dysfunction and obesity. Lymphatic endothelial cells (LECs) are crucial regulators of lymphatic barrier
function.…
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