grant
Lung Cancer FAST (Fragment Analysis, SNP, and Translocations) Testing
Organization CEREUS DIAGNOSTICS CORP.Location DALLAS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AccelerationAffectAmericanB-raf-1BRAFBRAF geneBackBiopsyBiopsy SampleBiopsy SpecimenC-K-RASCancer CauseCancer EtiologyCancer PatientCancersCapillary ElectrophoresisCapillary Electrophoresis FractionationCell LineCellLineCessation of lifeClinicalClinical DataClinical TrialsCytologyDNADNA mutationDataData SetDeathDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDiagnostic Reagent KitsDiseaseDisorderDorsumDrug TargetingDrugsEGF ReceptorEGFRERBB ProteinEnsureEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsFDA approvedFutureGene FrequencyGene variantGeneticGenetic ChangeGenetic MarkersGenetic defectGenetic mutationGoalsHER1HospitalsHourK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASLaboratoriesLifeLungLung Respiratory SystemMCF3Malignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMarketingMeasuresMedical centerMedicationMethodsMolecularMutationNCCNNGS MethodNGS systemNational Comprehensive Cancer NetworkNeedle biopsy procedureNon-Polyadenylated RNAOncogene K-RasPatientsPenetrationPharmaceutical PreparationsPopulation HeterogeneityProductionPulmonary CancerPulmonary malignant NeoplasmRAFB1RASK2RNARNA Gene ProductsROS1ROS1 geneReactionRecommendationReportingReproducibilityResearchResearch SpecimenRibonucleic AcidSamplingSingle Base PolymorphismSingle Nucleotide PolymorphismSpecificitySpecimenSpeedStrains Cell LinesTGF-alpha ReceptorTemperatureTestingTexasTherapeutic InterventionTimeTransforming Growth Factor alpha ReceptorUnited States Department of Veterans AffairsUnited States Veterans AdministrationUrogastrone ReceptorValidationVeterans AdministrationVeterans Affairsactionable mutationactionable variantsallelic frequencyallelic variantc-erbB-1c-erbB-1 Proteinclinical research siteclinical siteclinical validationclinically actionablecostcost effectivecultured cell linedetection limitdevelopmentaldiagnostic kitdiverse populationsdrug lot productiondrug/agenteffective therapyeffective treatmenterbB-1erbB-1 Proto-Oncogene ProteinerbBlfull scale manufacturinggene biomarkergene expression biomarkergene markergene signature biomarkergene testinggene-based testinggenetic biomarkergenetic testinggenetic variantgenome mutationgenomic variantheterogeneous populationimprovedintervention therapylarge scale manufacturinglarge scale productionlot productionlung cancermalignancymanufacturemanufacturing qualitymanufacturing systemsmass productionmeetingmeetingsminimally invasiveneedle biopsyneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingpopulation diversityproto-oncogene protein c-erbB-1prototyperapid detectionscale upsingle nucleotide varianttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttest kittrial planningtumortumor DNAtumor cell DNAtumor-specific DNAv-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homologv-ROS Avian UR2 Sarcoma Virus Oncogene Homolog 1v-raf Murine Sarcoma Viral Oncogene Homolog B1validation studiesvalidations
Description preview
Project Summary
Lung cancer is the leading cause of cancer deaths in the U.S., with over 235,000 diagnoses annually. Timely,
accurate testing is crucial for effective treatment, but current methods like Next Generation Sequencing (NGS)
are slow, costly, and ineffective for small biopsy samples. Cereus Diagnostics has developed Lung-FAST, a
rapid,…
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