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Longitudinal Modeling of Pro-Inflammatory Cytokines, Hazardous Alcohol Use, and Cerebral Metabolites as Predictors of Neurocognitive Change in People with HIV
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Jan 2024Deadline 15 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusAbstinenceAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAdultAdult HumanAlcohol Chemical ClassAlcohol DrinkingAlcohol abuseAlcohol consumptionAlcoholic beverage heavy drinkerAlcoholsB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BackBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBlood PlasmaBrainBrain Nervous SystemCerebrumCholineCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCognitive remediationConditioning TherapyCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDisease Frequency SurveysDisturbance in cognitionDorsumDrug TherapyEffectivenessEncephalonEtOH abuseEtOH drinkingEtOH useFutureGoalsGrantHIVHPGFHealthHeavy DrinkerHeavy DrinkingHepatocyte-Stimulating FactorHuman Immunodeficiency VirusesHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImpaired cognitionInflammationInflammatoryInterleukin-6InterventionIntervention StudiesLAV-HTLV-IIILinkLiquid substanceLiteratureLongitudinal StudiesLymphadenopathy-Associated VirusMGI-2MR SpectroscopyMagnetic Resonance SpectroscopyMeasuresMetabolicModelingMyeloid Differentiation-Inducing ProteinN-acetyl aspartateN-acetyl-L-aspartateN-acetylaspartateNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocognitiveNeurocyteNeuronsOutcomeParticipantPathway interactionsPerformancePersonsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPlasmaPlasma SerumPlasmacytoma Growth FactorPolypharmacyPopulationQOLQuality of lifeResearchReticuloendothelial System, Serum, PlasmaSamplingSecondary toTestingTimeUnited States National Institutes of HealthVirus-HIVVulnerable PopulationsWorkactive followupadulthoodadverse consequenceadverse outcomealcohol co-abusealcohol effectalcohol ingestionalcohol intakealcohol problemalcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeassess effectivenessbehavior interventionbehavioral interventionbrain healthcerebralco-morbidco-morbiditycognitive benefitscognitive changecognitive defectscognitive dysfunctioncognitive losscognitive performancecohortcomorbiditycytokinedetermine effectivenessdrink heavilydrinkingdrug adherencedrug compliancedrug interventiondrug treatmenteffectiveness assessmenteffectiveness evaluationethanol abuseethanol consumptionethanol drinkingethanol effectethanol ingestionethanol intakeethanol product useethanol useevaluate effectivenessexamine effectivenessexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionextreme drinkingfluidfollow upfollow-upfollowed upfollowuphazardous alcohol useheavy alcohol useimprovedinfancyinfantileinflammation markerinflammatory markerinsightinterferon beta 2intervention researchinterventional researchinterventional studyinterventions researchliquidlong-term studylongitudinal outcome studiesmedication adherencemedication compliancemyoinositolneural inflammationneuroinflammationneuroinflammatoryneuronalpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol usereduced alcohol useremediationresponsesecondary analysisstudy populationsystemic inflammationsystemic inflammatory responsesystemic interventiontimelinevulnerable groupvulnerable individualvulnerable people
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Description preview
PROJECT SUMMARY/ABSTRACT
Cognitive deficit is prevalent in people living with HIV. Mounting evidence has implicated systemic inflammation
and neuroinflammation in cognitive deficit via HIV-specific mechanisms; however, the cognitive effects of
longitudinal change in inflammation are poorly understood. Preliminary findings from a non-intervention…
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