grant
Longitudinal integration of environmental exposures, omics, and childhood NAFLD (LEON) Study
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 12 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAccelerationActive Follow-upAdolescentAdolescent YouthAdultAdult HumanAffectAir PollutionAnimal ModelAnimal Models and Related StudiesApproaches to preventionAutomobile DrivingBehaviorBehavioralBiologicalBiological MarkersBloodBlood Reticuloendothelial SystemCaliforniaCausalityChemicalsChildChild YouthChildhoodChildren (0-21)Children's HospitalCirrhosisClinicalClinical DataCluster AnalysesCluster AnalysisCommunitiesComplexCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataData ScienceDetectionDietary qualityDiseaseDisease Frequency SurveysDisease ProgressionDisorderEarly identificationEndocrine DisrupterEndocrine Disrupting ChemicalsEndocrine DisruptorsEndocrine disrupting agentEnrollmentEnvironmentEnvironmental ExposureEnvironmental PollutantsEnvironmental ToxinEnzyme GeneEnzymesEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEtiologyExposure toExtrahepaticFamilyFatsFatty acid glycerol estersFecesFibrosisFundingGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenomicsGoalsHealthHepaticHepatic TransplantationHigh PrevalenceHumanIndividuals from minorityIndividuals of minorityIndustrial WasteInflammationInherited PredispositionInherited SusceptibilityInjury to LiverInvestigationLatinoLatino PopulationLatino groupLatino individualLatino peopleLatinosLife StyleLifestyleLipidsLiverLiver GraftingLiver TransplantLos AngelesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasurementMeasuresMediationMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMethodologyMethodsMinority GroupsMinority PeopleMinority PopulationMinority individualModern ManMolecularMolecular FingerprintingMolecular ProfilingMorbidityMorbidity - disease rateMultiomic DataNAFLDNASHNMR ImagingNMR TomographyNegotiatingNegotiationNeighborhoodsNuclear Magnetic Resonance ImagingPathologyPathway interactionsPediatric HospitalsPesticidesPhysiologicPhysiologicalPlasticizersPopulationPrevalencePreventative strategyPrevention approachPrevention strategyPreventive strategyProteomicsPublic HealthQuestionnairesRacial GroupResearchResearch DesignResearch ResourcesResearch SpecimenResourcesRiskRisk FactorsSample SizeSeverity of illnessSocial statusSpecimenStudy TypeSubgroupToxic Environmental AgentsToxic Environmental SubstancesUnderserved PopulationUnhealthy DietUrineYouthYouth 10-21Zeugmatographyactive followupadulthoodbio-markersbiologicbiologic markerbiomarkerburden of diseaseburden of illnesscausationchild adipositychild obesitychildhood adipositychildhood obesitychronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disordercirrhoticdata integrationdiet qualitydietarydisease burdendisease causationdisease phenotypedisease riskdisease severitydisorder riskdisparity in healthdrivingendocrine disrupting compoundenrollenvironmental contaminantenvironmental toxicantepidemiologicepidemiologicalepigeneticallyepigenomicsethnic subgroupethnicity groupexperienceexposomefatty liver diseasefollow upfollow-upfollowed upfollowupgenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedhealth datahealth disparityhepatic body systemhepatic damagehepatic injuryhepatic organ systemhepatocyte injuryhigh dimensionalityhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationimage-based methodimaging methodimaging modalityimprovedindividualized preventionindustrial pollutantinnovateinnovationinnovativeinsightjuvenilejuvenile humankidslife-style factorlifestyle factorsliver damageliver injuryliver transplantationlow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmalleable riskmetabolism measurementmetabolomicsmetabonomicsmetagenome sequencingmetagenomic sequencingmicrobiomemodel of animalmodifiable riskmolecular profilemolecular signaturemultidisciplinarymultiomicsmultiple omic datamultiple omicsnon-alcohol fatty liver diseasenon-alcohol induced steatohepatitisnon-alcoholic fatty liver diseasenon-alcoholic liver diseasenon-alcoholic steato-hepatitisnon-alcoholic steatohepatitisnonalcoholic fatty liver diseasenonalcoholic steato-hepatitisnonalcoholic steatohepatitisobese childrenobesity during childhoodobesity in childrenpanomicspathwaypediatricpediatric NAFLDpediatric non-alcoholic fatty liver diseasepediatric nonalcoholic fatty liver diseasepediatric obesitypersonalized preventionphenotypic datapollutantpoor dietprecision preventionracial populationracial subgrouprecruitresponsesocialsocial factorssocial health determinantssocial positionsocial standingspecific biomarkersstoolstudy designtooltoxic metaltoxicanttranscriptomicstrendunder served groupunder served individualunder served peopleunder served populationunderserved groupunderserved individualunderserved peopleyoungsteryouth age
Description preview
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the pediatric population
with a projected 20% increase in prevalence over the next 10 years. NAFLD in children is more likely than in
adults to be characterized by hepatocyte injury in portal regions, reflecting a more severe disease type. Latinos
are…
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