grant
Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 25 Sept 2017Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AIDS NephropathyAIDS-Associated NephropathyAIDS-Related NephropathyAcademic Medical CentersAccelerationActive Follow-upAcuteAddressAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAlbuminsAllograftingAmericanAntibodiesApolipoproteinsBacterial InfectionsBiologicalBiopsyBlack AmericanBloodBlood Reticuloendothelial SystemBlood SerumChronicClinicalClinical DataCommunitiesConsentCost SavingsCounselingCreatinineDNADataDeoxyribonucleic AcidDisadvantagedDisparitiesDisparityDisparity populationDonor ExclusionsDonor personESKDESRDEconomic FactorsEconomical FactorsEducationEducational aspectsEligibilityEligibility DeterminationEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnrollmentEnsureEnvironmental FactorEnvironmental Risk FactorEuropeanEvaluationFSGSFaceFailureFocal and Segmental GlomerulosclerosisFocal segmental glomerular sclerosisFoundationsGenesGeneticGenetic RiskGenetic ScreeningGenetic predisposing factorGenotypeGeographyGoalsGraft SurvivalHIV-Associated NephropathyHIV-Related NephropathyHL-A AntigensHLA AntigensHealth Care CostsHealth CostsHuman Immunodeficiency Virus-Associated NephropathyHuman Leukocyte AntigensHypertensionImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInformed ConsentKidneyKidney DiseasesKidney FailureKidney GraftingKidney InsufficiencyKidney TransplantationKidney TransplantsKidney Urinary SystemKnowledgeLesionLeukocyte AntigensLiving DonorsLong-term Follow-upMeasuresMedicalNIH RFANational Institutes of HealthNephropathyOrganOrgan ProcurementsOutcomeParticipantPatternPhasePhenotypePoliciesPopulationPrevalenceProteinuriaProtocol ScreeningQOLQualifyingQuality of lifeRecurrent diseaseRegistriesRelapsed DiseaseRenal DiseaseRenal FailureRenal GraftingRenal InsufficiencyRenal TransplantationRenal TransplantsRenal functionReportingRequest for ApplicationsResearchRiskRisk-associated variantRoleSafetySerumSiteSlideTimeTransplant RecipientsTransplantationUNOSUnited Network for Organ SharingUnited States National Institutes of HealthUniversitiesUniversity Medical CentersUrineVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderViral DiseasesVirus DiseasesWorkacademic programactive followupbacteria infectionbacterial diseasebiologicclinical centercohortdeceased donordeceased organ donorsdepositorydifferences due to racedifferences in racediffers by racediffers in racedigital pathologydisadvantaged groupdisadvantaged individualdisadvantaged peopledisadvantaged populationdisadvantaged subgroupdisparities across groupsdisparity across subgroupsdisparity among groupsdisparity among subgroupsdisparity between groupsdisparity between subgroupsenrollenvironmental riskethnic differenceethnicity differenceexperiencefacesfacialfollow upfollow-upfollowed upfollowupgenetic risk factorgraft failuregroup disparitygroup inequalitygroup inequityhigh blood pressurehigh riskhyperpiesiahyperpiesishypertensive diseasehypertensive disorderimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinequalities among populationsinequalities between populationsinequalities in populationsinequality across populationsinequality among groupsinequality between groupsinequality in groupsinequities among populationsinequities between populationsinequities in populationsinequity across groupsinequity across populationsinequity between groupsinequity in groupsinherited factorkidney biopsykidney developmentkidney disorderkidney functionkidney txlive kidney donorliving kidney donorlong-term followupnephrogenesisnon-diabeticnondiabeticnovelorgan allocationpopulation inequalitypopulation inequitypost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationprimary outcomeprogramsprospectiverace based differencesrace differencesrace related differencesracial differenceracially differentrecruitrenalrenal biopsyrenal disorderrepositoryresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsecondary outcomesocialsocial rolesubgroup disparitytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttransplanttransplant centerstransplant donortransplant patientunequal groupunequal populationviral infectionvirus infectionvirus-induced disease
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Description preview
An excess burden of chronic kidney and end stage renal disease is experienced by Black Americans.
Risk variants in the apolipoprotein-1 (APOL1) gene, found almost exclusively in individuals of African ancestry,
are associated with several forms of non-diabetic kidney disease in Black Americans, including focal
segmental glomerulosclerosis,…
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