grant
Long-range coordination of planar polarity
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAnimalsAvesAvianBehaviorBiologic ModelsBiological ModelsBirdsBody TissuesCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell PolarityCell SignalingCellsCellular MigrationCellular MotilityCommunicationCongenital Cardiac DefectsCongenital Heart DefectsConsensusCouplesCuesDNA mutationDefectEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEmbryonic TissueEpidermisFeathersGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGoalsGrowthIntegral Membrane ProteinIntracellular Communication and SignalingIntrinsic Membrane ProteinLeadLinkMammaliaMammalsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsModel SystemModelingMorphologyMurineMusMutationNeural Tube ClosurePathway interactionsPatternPb elementPhenotypeProcessPropertyProteinsResearchRoleSideSignal TransductionSignal Transduction SystemsSignalingSkinSurface ProteinsTissue DifferentiationTissue GrowthTissuesTransmembrane ProteinTransmembrane Protein GeneVariantVariationbiological signal transductioncell behaviorcell motilitycellular behaviorcellular polaritydevelopmental diseasedevelopmental disorderembryo tissueextracellulargenome mutationheavy metal Pbheavy metal leadinsightinterestontogenypathwayplanar cell polarityself organizationsocial roletrafficking
Description preview
Project Summary
The highly conserved Planar Cell Polarity (PCP) pathway is essential for cells to communicate directional
information between neighboring cells to drive collective cell movements and oriented cell behaviors during
embryonic development. Disruptions in PCP signaling lead to severe developmental disorders including
congenital heart…
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