grant
Local Delivery of AdipoRon to Treat Arthrofibrosis
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 7 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025ACRP30 proteinAberrant TissueAddressAdipocytesAdipose CellAdipose tissueApproaches to preventionAutologous Fibrin Tissue AdhesiveAutomobile DrivingBiochemicalBiocompatible MaterialsBiomaterialsBiomechanicsBody TissuesBone-Derived Transforming Growth FactorCell Communication and SignalingCell Culture TechniquesCell SignalingCell-Extracellular MatrixCharacteristicsChoristomaCicatrixComplexComplicationContractureCulturing, in vitro Vertebrate, PrimaryDataDepositDepositionDevelopmentDifferentiation in cell cultureDiseaseDisorderDomestic RabbitDoseDrug DeliveryDrug Delivery SystemsDrug TherapyECMEctopic TissueEndocrine Gland SecretionEnvironmentExhibitsExtracellular MatrixFat CellsFatsFatty TissueFatty acid glycerol estersFibrin AdhesiveFibrin GlueFibrin SealantFibrin Sealant SystemFibrin Tissue AdhesiveFibrinogen AdhesiveFibroblastsFibrosisFosteringGenerationsHeterotopic TissueHormonesHumanIn VitroIn vitro cell differentiationInflammationInterventionIntracellular Communication and SignalingJointsKneeKnee arthroplastyKnee joint replacement operationKnee replacementKnowledgeLipocytesMature LipocyteMature fat cellMeasuresMediatingMethodologyMiceMice MammalsMilk Growth FactorModalityModelingModern ManMolecularMorbidityMorbidity - disease rateMotionMurineMusMusculoskeletal DiseasesMyofibroblastOnset of illnessOperative ProceduresOperative Surgical ProceduresOryctolagus cuniculusPK/PDPainPainfulPathway interactionsPatientsPharmacological TreatmentPharmacotherapyPhysiatric ProcedurePhysical Medicine ProcedurePhysical TherapeuticsPhysical therapyPhysiotherapyPlatelet Transforming Growth FactorPre-Clinical ModelPreclinical ModelsPredispositionPreventionPrevention approachPreventivePrimary Cell CulturesProcessPropertyRNA SeqRNA sequencingRNAseqRabbitsRabbits MammalsResistanceRoleScarsSecond LookSecond Look SurgerySignal TransductionSignal Transduction SystemsSignalingSurgicalSurgical InterventionsSurgical ProcedureSurgical RevisionSusceptibilitySymptomsTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTherapeutic HormoneTherapeutic InterventionTisselTissuesTotal Knee ReplacementTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTraumaUnited Statesadipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadipocytokinesadipokinesadiponectinadiposeanalogapM-1 proteinapM1 (adipose-specific) proteinbiological materialbiological signal transductionbiomechanicalcell culturecell culturesclinical relevanceclinically relevantcombatcostdevelopmentaldifferentiation in culturedifferentiation in vitrodisease onsetdisorder onsetdrivingdrug interventiondrug treatmenthealingimprovedin vitro cellular differentiationin vivoindexinginnovateinnovationinnovativeintervention therapyknee replacement arthroplastymimeticsmusculoskeletal disordernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypharmaceutical interventionpharmacokinetics and pharmacodynamicspharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinicalpreclinicalpreventpreventingresistantresponsescRNA sequencingscRNA-seqside effectsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesurgerytisseeltotal knee arthroplastytranscriptome sequencingtranscriptomic sequencingwhite adipose tissueyellow adipose tissue
Description preview
ABSTRACT
Arthrofibrosis is a debilitating condition that limits joint motion and causes substantial pain. It is a common
complication (~5%) following routine total knee arthroplasty (TKA) and its symptoms are often resistant to
pharmacological treatments, physical therapy, and revision surgeries. While aberrant extracellular matrix
generation is…
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