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Local and global epigenome regulation of senescence and aging
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAcetyl CoAAcetyl Coenzyme AAcetylationAgeAgingAnimal ModelAnimal Models and Related StudiesAutomobile DrivingAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBody TissuesCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCaloric RestrictionCell AgingCell BodyCell FunctionCell NucleusCell PhysiologyCell ProcessCell SenescenceCell divisionCell modelCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceCellular modelCessation of lifeChromatinCommunitiesComplexDataDeathDeteriorationDiseaseDisorderDrug TherapyDysfunctionEnhancersEnzyme GeneEnzyme InteractionEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotaEukaryoteFunctional disorderFundingFutureGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGenomeHistone AcetylaseHistone AcetylationHomeostasisHumanIntervening SequencesInterventionIntronsInvestigationKnowledgeLength of LifeLinkLiverLongevityMaintenanceMemoryMetabolicMiceMice MammalsModelingModern ManMolecular InteractionMurineMusNuclearNucleusPathway interactionsPharmacological TreatmentPharmacotherapyPhenotypePhysiological HomeostasisPhysiopathologyPlayProcessPyruvateRNA ExpressionRegulationRegulatory PathwayReplicative SenescenceResearchRoleS-acetate Coenzyme ASeminalSomatic MutationSubcellular ProcessTherapeuticTimeTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription InitiationTranscription factor genesWorkage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagesaging associatedaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging induced epigenetic changeaging relatedaging related alterationsaging related changesaging specific alterationsaging specific changesaging-associated epigenetic changeaging-related epigenetic changealterations with ageattenuation of senescencecalorie restrictionchanges with ageclustered regularly interspaced short palindromic repeats screendecline in functiondecline in functional statusdecrease senescencedelay senescencedrivers of agingdrivingdrug interventiondrug treatmentenhance healthspanepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigeneticallyepigenomeextend healthspanextending healthy lifespanfunctional declinefunctional status declinegenetic approachgenetic strategygerodriverhealthspan extending interventionhealthspan extending therapieshealthspan extensionhealthspan interventionhealthspan promoting interventionhealthspan promoting therapieshealthspan therapieshealthy aginghealthy aging interventionhealthy human aginghepatic body systemhepatic organ systemhistone acetyltransferaseimprove healthspanimprovedincrease healthspanintervention to promote healthy aginginterventions to improve healthspanliver functionmodel of animalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-geneticnongeneticnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathophysiologypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprolong healthspanpromote healthspanpromoterpromotorrecruitreduce senescencereducing cellular senescencereplicative agingrepress senescencesenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescence mitigationsenescentsenescent associated secretomesenescent associated secretory phenotypesocial rolesomatic variantsuppress senescencethree dimensionaltranscription factor
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Description preview
Project summary
Chromatin and epigenetic information influences gene expression without changing the underlying genome
and can provide cellular memory through cell division. Epigenetic mechanisms are under intense investigation
for regulation of age-related changes in phenotype, including age-related changes in gene expression and
disease states.…
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