grant
Loaded Fibrin-Specific Nanogels for Sepsis-Induced DIC
Organization NORTH CAROLINA STATE UNIVERSITY RALEIGHLocation RALEIGH, UNITED STATESPosted 30 Sept 2024Deadline 29 Sept 2028
NIHUS FederalResearch GrantFY2025AcuteAddressAdjuvant TherapyAffectAlteplaseAnimal Disease ModelsAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAnticoagulant AgentsAnticoagulant DrugsAnticoagulantsAntithrombotic AgentsAntithrombotic DrugsBiodistributionBleedingBlood Coagulation DisordersBlood Coagulation FactorBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneBlood NeutrophilBlood PlasmaBlood Platelet CountBlood Platelet NumberBlood PlateletsBlood Polymorphonuclear NeutrophilBone MarrowBone Marrow ExaminationBone Marrow Reticuloendothelial SystemCancersCanine SpeciesCanis familiarisCardiovascular DiseasesCell CommunicationCell InteractionCell modelCell-to-Cell InteractionCellular modelCirculationClinicalClinical TrialsClottingCoagulationCoagulation DisorderCoagulation Factor ICoagulation Factor OneCoagulation FactorsCoagulation ProcessCoagulopathyCommon Rat StrainsConsumptionConsumption CoagulopathyD-dimerD-dimer fibrinD-dimer fragmentsDataDeath RateDepositDepositionDevelopmentDiseaseDisorderDisseminated Intravascular CoagulationDogsDogs MammalsDoseDrug DeliveryDrug Delivery SystemsDrugsDysfunctionEndotheliumEnvironmentFactor IFactor OneFibrinFibrin fragment DFibrinogenFibrinolysesFibrinolysisFibrinolytic AgentsFibrinolytic DrugsFreeze DryingFreeze DryingsFunctional disorderGestationGoalsHealth CareHemorrhageHemostasisHemostatic functionHumanIn VitroIndividualInjuryLaboratoriesLearningLife ExpectancyLipopolysaccharidesLyophilizationMalignant NeoplasmsMalignant TumorMarrow NeutrophilMarrow plateletMaximal Tolerated DoseMaximally Tolerated DoseMaximum Tolerated DoseMedicationMentorshipModelingModern ManMorphologyN-isopropylacrylamideNanoGelNatureNeutrophilic GranulocyteNeutrophilic LeukocyteNorth CarolinaOrganOutcomePathologic ProcessesPathological ProcessesPathologyPharmaceutical PreparationsPhenotypePhysiopathologyPlasmaPlasma SerumPlatelet CountPlatelet Count measurementPlatelet NumberPlateletsPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPregnancyProtocolProtocols documentationPublic HealthRatRats MammalsRattusRecombinant Tissue Plasminogen ActivatorResearchResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaRiskRodent ModelRoleSafetyScientistSepsisSiteSpleenSpleen Reticuloendothelial SystemStructureStudentsT-Plasminogen ActivatorTestingThrombaseThrombinThrombocytesThrombocytopeniaThrombolytic AgentsThrombolytic DrugsThrombopeniaThrombusTissue Activator D-44Tissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTrainingTranslational ResearchTranslational ScienceTraumaTreatment ProtocolsTreatment RegimenTreatment ScheduleUniversitiesWorkadjuvant treatmentanti-microbial resistance emergenceantimicrobial resistance emergenceantisepsis treatmentantithrombotic medicationantithromboticsbleeding disorderblood lossblood thinnerbone marrow examcaninecardiovascular disorderclotting disorderclotting factorcrosslinkdevelopmentaldomestic dogdosagedrug/agenteffective therapyeffective treatmentemerging anti-microbial resistanceemerging antimicrobial resistanceextracellularfibrin fragment D-dimerfibrin fragment D1 dimerfibrin fragment DDfibrinogenasehuman diseaseimprovedin vivoin vivo Modelinjuriesinjury responseinjury to organsmalignancymigrationmodel of animalmortalitymortality ratemortality rationeoplasm/cancerneutrophilnovelorgan injurypathophysiologyresponseresponse to injurysepsis caresepsis interventionssepsis managementsepsis therapeuticssepsis therapysepsis treatmentseptic therapyseptic treatmentside effectsite targeted deliveryskillssocial rolet-PAtargeted deliverytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthrombopoiesis inhibitortranslation researchtranslational investigationtranslational investigatortranslational researchertranslational scientisttreat sepsis
Description preview
PROJECT SUMMARY
Disseminated intravascular coagulation (DIC) is the pathophysiologic response to injury that leads to the
formation of microthrombi and subsequent activation of fibrinolysis. DIC is characterized by the consumption of
platelets, fibrinogen, and clotting factors, and it can present clinically with prothrombotic and/or hemorrhagic…
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