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Lipid hydroperoxides in sarcopenia and muscle wasting: mechanisms and intervention
Organization OKLAHOMA CITY VA MEDICAL CENTERLocation OKLAHOMA CITY, UNITED STATESPosted 1 Jan 2022Deadline 5 Jun 2025 ⚠️
VANIHUS FederalResearch GrantFY202515-LOX15-LipoxygenaseAccelerationAgeAge MonthsAge YearsAgingAnimal GeneticsAnimal ModelAnimal Models and Related StudiesArachidonate 15-LipoxygenaseArachidonate Omega-6 LipoxygenaseArachidonic Acid 15-LipoxygenaseArachidonic AcidsAtrophicAtrophyAttenuatedBody CompositionCessation of lifeCommunicationCytoplasmDNA TherapyDataDeathDenervationDevelopmentDiabetes MellitusDysfunctionEC 3.1.1.4EicosanoidsElectron TransportEnzyme GeneEnzymesFatty Acid HydroperoxidesFiberFractureFunctional disorderGene Transfer ClinicalGenerationsGeneticGenetic InductionGenetic InterventionGoalsGrip strengthH2O2Hand StrengthHealthHealth ExpendituresHindlimbHydrogen PeroxideHydroperoxideInterventionKO miceKnock-out MiceKnockout MiceLecithinase A2Lipid HydroperoxideLipid PeroxidationLipid PeroxidesLipidsLipoperoxidesMaintenanceMalnutritionMeasuresMediatorMembraneMental DepressionMentorsMetabolic Protein DegradationMiceMice MammalsMitochondriaModelingMorphologyMotor CellMotor NeuronsMovementMurineMusMuscleMuscle AtrophyMuscle FibersMuscle ProteinsMuscle TissueMuscle functionMuscular AtrophyMyoneural JunctionMyotubesNeuromuscular JunctionNull MouseNutritional DeficiencyOxidative StressPLA2PatientsPermeabilityPhosphatidesPhospholipase A2PhospholipidsPhysiopathologyPopulationPrevalenceProductionProtein BiosynthesisProtein TurnoverProteinsPsyche structureQOLQuality of lifeRegulatory Protein DegradationResearch TechnicsResearch TechniquesReticulocyte Arachidonate 15-LipoxygenaseRhabdomyocyteRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRiskRunningScientistSecondary toSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesStructureSuperoxide AnionSuperoxide RadicalSuperoxidesSyndromeTestingTrainingUndernutritionVeteransVoluntary Muscleadverse consequenceadverse outcomeage associatedage associated muscle atrophyage correlatedage dependentage linkedage relatedage specificage-associated decline in muscleage-associated muscle declineage-associated muscle deteriorationage-associated muscle lossage-associated muscle wastingage-related decline in muscleage-related muscle declineage-related muscle deteriorationage-related muscle lossage-related muscle wastingaged miceaged mouseaged muscleagesaging of muscleattenuateattenuatesbody movementbone fracturecatalaseconferenceconventiondecreased muscle massdepressiondesigndesigningdevelopmentaldiabetesdietary deficiencyeffective interventioneffective therapyeffective treatmentelderly miceelectron transferexperimentexperimental researchexperimental studyexperimentsfallsgene repair therapygene therapygene-based therapygenetic therapygenomic therapyglutathione peroxidasehealth care expenditurehealthspanhealthy life spanimprovedinnervationintervention designlecithinase Alipid peroxidelow muscle massmalnourishedmedical expendituremeetingmeetingsmembrane structurementalmitochondrialmitochondrial dysfunctionmodel of animalmotoneuronmouse modelmurine modelmuscle agingmuscle breakdownmuscle bulkmuscle degenerationmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle strengthmuscle wastingmuscularnerve supplynovelnutrition deficiencynutrition deficiency disordernutritional deficiency disorderold miceoverexpressoverexpressionoxidationpathophysiologypharmacologicphosphatidasephosphatidolipasephosphatidylcholine 2 acylhydrolasephysical disabilityphysically disabledphysically handicappedprotein biomarkersprotein degradationprotein markersprotein synthesisreduced muscle massresponsesarcopeniasarcopenicskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle protein lossskeletal muscle wastingstable isotopesummitsymposiasymposiumtherapeutic targettherapy designtreatment design
Applications closed.
Description preview
SIGNIFICANCE TO VETERANS HEALTH: Two-thirds of all veterans are 55 years of age or older. Sarcopenia
is a syndrome that effects approximately 25% of the U.S. population over the age of 70 characterized by
progressive loss of skeletal muscle mass and strength with an increased risk of adverse outcomes such as
physical disability, poor quality of…
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