grant
Linking Mechanism to Outcome in Airway Inflammation and Remodeling
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AffectAirway DiseaseAllergyAreaAssayAsthmaB cell growth factorB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1Basal CellBinetrakinBioassayBiological AssayBiologyBody TissuesBronchial AsthmaCCL26CCL26 geneCD124Cell DifferentiationCell Differentiation processCell FunctionCell PhysiologyCell ProcessCellular AssayCellular FunctionCellular PhysiologyCellular ProcessCenter for Translational Science ActivitiesChIP SequencingChIP-seqChIPseqChemokine, CC Motif, Ligand 26Chemotactic CytokinesChromatinClinicalClinical ImmunologyClinical SciencesClinical TreatmentComputational BiologyCys-LTDataData BasesData SetDatabasesDedicationsDefectDevelopmentDiseaseDisorderDysfunctionEOTAXIN 3Educational workshopEmbryoEmbryonicEnsureEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumFISH TechnicFISH TechniqueFISH analysisFISH assayFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FacultyFluorescence In Situ HybridizationFluorescent in Situ HybridizationFunctional disorderFundingFutureGene ExpressionGenesGeneticGoalsGrantHealth Care CostsHealth CostsHomologous Chemotactic CytokinesHospitalsIL-13IL-4IL13IL4 ProteinIL4RIL4R geneIL4RAImmuneImmunesImmunogenomicsImmunologyInflammationInflammatoryInstitutionIntercrinesInterleukin-13Interleukin-4Interleukin-4 PrecursorInvestigatorsJunior PhysicianK24 MechanismK24 ProgramKnowledgeLinkLymphocyte Stimulatory Factor 1MCGF-2Machine LearningMast Cell Growth Factor-2Mechanistic Target of RapamycinMemoryMentorsMesenchymalMetabolicMidcareer Investigator Award in Patient-Oriented ResearchMidcareer Investigator Award in Patient-Oriented Research (K24)MolecularMorbidityMorbidity - disease rateMultiple PolypsNasalNasal Cavity PolypNasal Passages NoseNasal PolypsNoseObservation researchObservation studyObservational StudyObservational researchOutcomePathogenesisPathway interactionsPatientsPh D studentPh D. studentPh. D. studentPh.D studentPh.D. studentPhD studentPhD. studentPhysiopathologyPlayPolypsPopulationPostdocPostdoctoral FellowPreventative strategyPreventionPrevention strategyPreventive strategyProductionProspective StudiesPublishingRAFT1ResearchResearch AssociateResearch PersonnelResearchersRespiratory EpitheliumRespiratory System, Nose, Nasal PassagesRoleSCYA26SIS cytokinesSamter's triadScientistSeriesSmall Inducible Cytokine Subfamily A, Member 26Structure of respiratory epitheliumSubcellular ProcessT-Cell Growth Factor 2TSLPTSLP geneTechnologyTestingThymic Stromal LymphopoietinTissuesTrainingTranslatingTransposaseValidationWomanWorkWorkshopWound Repairairway epitheliumairway epithelium inflammationairway inflammationairway remodelingaspirin-exacerbated respiratory diseaseaspirin-induced asthmaburden of diseaseburden of illnesscell assaycellular differentiationchemoattractant cytokinechemokinechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic airway diseasechronic inflammatory diseasechronic respiratory diseasechronic rhinosinusitisclinical interventionclinical therapycohortcomplex datacomputer biologycysteinyl-leukotrienecytokinedata basedevelopmentaldisease burdendisease controldisorder controldoctoral studenteffective therapyeffective treatmentepigeneticallyepigenomeinvestigator trainingmTORmachine based learningmammalian target of rapamycinmeetingmeetingsnext generationnovelpathophysiologypathwaypatient centeredpatient orientedpatient oriented researchpatient oriented studypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpolyposispost-docpost-doctoralpost-doctoral traineepre-docpre-doctoralpreventpreventingprogenitorprogramsresearch associatesrespiratory inflammationrespiratory tract epitheliumrespiratory tract inflammationresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolestemtranscriptomicstranslational research centertranslational sciences centertranslational studytrial regimentrial treatmentvalidationswound healingwound recoverywound resolution
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PROJECT SUMMARY
Chronic rhinosinusitis (CRS) and asthma are common chronic inflammatory diseases that cause substantial morbidity and account for > 50 billion dollars a year in healthcare costs. Barrier epithelial cells play a central role in the initiation and persistence of each disease. Despite advances in sequencing, and growing databases of…
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