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Linking lifestyles with tumor immune profiles to identify strategies for improving breast cancer outcomes
Organization ROSWELL PARK CANCER INSTITUTE CORPLocation BUFFALO, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AddressAdherenceAfter CareAfter-TreatmentAftercareAlcohol DrinkingAlcohol consumptionAmericanAmerican Cancer SocietyBiologicalBreast CancerBreast Cancer ModelBreast Cancer PatientBreast NeoplasmsBreast Tumor PatientBreast TumorsBreast tumor modelCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancer PrognosisCancersCell BodyCell DensityCellsCessation of lifeClinicalDataData BanksDatabanksDeathDevelopmentDiagnosisDietEatingEpidemiologyEtOH drinkingEtOH useExerciseFood IntakeGuidelinesHealthHigh Fat DietImmuneImmune MarkersImmune mediated therapyImmune systemImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic MarkersImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyInfiltrationInvestigationKnowledgeLife StyleLifestyleLinkMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMammary CancerMammary NeoplasmsMediatingMediationMolecular Tumor SuppressionNegotiatingNegotiationNetwork AnalysisObesityOutcomePathway AnalysisPatientsPhenotypePhysical activityPopulationPreparationProcessed MeatsPublishingRecommendationRecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorReportingResearchRoleRunningSiteSmokingStaining methodStainsSuggestionT8 CellsT8 LymphocytesTNBCTeff cellTestingTherapeuticTreatment EfficacyTumor ImmunityTumor SuppressionTumor TissueWomanWorkadiposityaggressive breast canceralcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeanti-cancer researchanti-tumor immunityantitumor immunitybiobankbiologicbiorepositorybreast cancer survivalcancer diagnosiscancer immunitycancer preventioncancer progressioncancer recurrencecancer researchcancer sub-typescancer subtypescancer survivalclinical significanceclinically significantcorpulencedata depositorydata repositorydata set repositorydataset repositorydesigndesigningdevelopmentaldietseffector T cellepidemiologicepidemiologicalethanol consumptionethanol drinkingethanol ingestionethanol intakeethanol product useethanol useexhaustexperiencefruits and vegetableshealthy lifestylehealthy weighthigh riskimmune microenvironmentimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based biomarkersimmune-based therapiesimmune-based treatmentsimmuno therapyimmunohistochemical biomarkersimmunohistochemical markersimmunological biomarkersimmunological markersimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedindexingindividuals with breast cancerinsightintervention efficacylife style interventionlife-style datalife-style factorlifestyle datalifestyle factorslifestyle interventionmalignancymalignant breast tumormammary cancer modelmammary tumormammary tumor modelmortalityneoplasm progressionneoplasm/cancerneoplastic progressionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparticipant enrollmentpatient enrollmentpatients with breast cancerperipheral bloodperson with breast cancerpost treatmentpre-clinicalpreclinicalpreparationspreventpreventingresponse to therapyresponse to treatmentsocial rolespatial relationshipstandard of caresugarsweetened beveragetherapeutic efficacytherapeutic responsetherapy efficacytherapy responsetraffickingtreatment responsetreatment responsivenesstriple-negative breast cancertriple-negative invasive breast carcinomatumortumor growthtumor immune microenvironmenttumor progressiontumor-immune system interactions
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Description preview
A developing body of preclinical evidence suggests that the integrity and composition of the tumor immune
microenvironment (TIME) is highly plastic and is modulated by host lifestyle exposures. Unhealthful exposures
including obesity, inactivity and a high fat diet can lead to a loss of CD8+ T cell effector function and tumor
progression in…
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