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Light Sensitivity in Bipolar Disorder: A Potential Driver of Variability in Sleep, Mood and Energy

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldActinotherapyAdultAdult HumanAffectAgeAnxietyBipolar Affective PsychosisBipolar DisorderBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCircadian RhythmsClinicalDepressed moodDrugsEcological momentary assessmentEncephalonEnrollmentEnsureExposure toEyeEyeballFutureGlassIlluminationIndividualIndividual DifferencesIntracellular Communication and SignalingLaboratoriesLi+ elementLightLight SensitivityLight TherapyLightingLinkLithiumLongitudinal StudiesManiasManicManic StateManic-Depressive PsychosisMeasuresMedicationMelatoninMental DepressionMood stabilizersMoodsNyctohemeral RhythmParticipantPathologicPatient Self-ReportPatternPersonsPharmaceutical PreparationsPhotophobiaPhotoradiationPhotoradiation TherapyPhototherapyPlayPolysomnographyProtocolProtocols documentationPupilQuestionnairesRecommendationReportingResearchRetinaRetinal Ganglion CellsRiskRoleSamplingSeasonsSelf-ReportShapesSignal TransductionSignal Transduction SystemsSignalingSleepSleep MonitoringSleep disturbancesSomnographySunlightSystemTestingTherapeutic TrialsTimeTwenty-Four Hour RhythmUnipolar DepressionWristaberrant sleepactigraphactigraphyadulthoodagesanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsbiological signal transductionbipolar affective disorderbipolar diseasebipolar illnessbipolar mood disordercircadiancircadian processcircadian rhythmicitycohortdaily biorhythmdepresseddepressiondisabilitydisrupted sleepdisturbed sleepdrug/agentenrollexposure to lightexposure to visible lightimpaired sleepirregular sleeplight exposurelight interventionlight pollution exposurelight treatmentlong-term studylongitudinal outcome studiesmanic depressive disordermanic depressive illnessmelanopsinmortalityresponseretinal ganglionsadnesssexsleep amountsleep disruptionsleep durationsleep dysregulationsleep episodesleep intervalsleep lengthsleep measurementsleep periodsleep polysomnographysleep quantitysleep timesleep/wake disruptionsleep/wake disturbancesocial rolesun lighttime asleeptime during sleeptime in sleeptime spent asleeptime spent sleeping

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Description preview

ABSTRACT
Bipolar disorder I (BD1) is characterized by pathological mood swings ranging from mania (e.g., high energy,
minimal sleep) to depression (e.g., low energy, increased/decreased sleep). BD affects ~2% of adults, and is
associated with increased disability and mortality. Disrupted sleep and circadian patterns are a primary feature
of BD.…

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