grant
Life-space, isolation, and functional exposome study in preclinical Alzheimer's disease and cognitive environments (LIFESPACE)
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Jun 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY202565 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldA β-42A β42A-beta 42A-beta42AD dementiaAD related dementiaADRDAbeta-42Abeta42AccelerometerActivities of Daily LivingActivities of everyday lifeAgeAged 65 and OverAirAir PollutionAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmentiaAmyloid beta-42Amyloid beta42Amyloid β-42Amyloid β42Amyloidβ-42Amyloidβ42AreaAutomobile DrivingAβ-42Aβ42BehaviorBiologicalBiological MarkersBiologyBlood PlasmaCell Communication and SignalingCell SignalingChronicClinicalClinical TreatmentClinical TrialsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunitiesComplexDataDementiaDestinationsDigital biomarkerDisease ProgressionDisturbance in cognitionDrugsEarly DiagnosisEducationEducational aspectsEnvironmentFamilyFingerprintFrequenciesFriendsGeneralized GrowthGenetic MarkersGeographyGoalsGreen spaceGrowthHealthHealth PrioritiesImpaired cognitionImpairmentIndividualIndividuals from minorityIndividuals of minorityInfrastructureInstitutionIntracellular Communication and SignalingKnowledgeLifeLocationLong-term prospective studiesLow incomeMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMedicationMental DepressionMinority GroupsMinority PeopleMinority PopulationMinority individualModelingMolecularMonitorMovementNeighborhoodsNormalcyNormalitiesOutcomePM2.5PathologicPatient Self-ReportPatternPersonsPharmaceutical PreparationsPhysical activityPlasmaPlasma SerumPopulationPrevalencePreventionPrimary Senile Degenerative DementiaR-Series Research ProjectsR01 MechanismR01 ProgramRaceRacesResearch GrantsResearch Project GrantsResearch ProjectsReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleRuralSamplingSelf-ReportSignal TransductionSignal Transduction SystemsSignalingSiteSocial InteractionSocial MobilitySocial NetworkSocial isolationSocial supportStressSymptomsTestingTimeTissue GrowthUnited StatesVisitabove age 65accelerometryactivity monitoractivity trackerafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged ≥65agesalzheimer riskamnestic mild cognitive impairmentbehavior influencebehavioral influencebio-markersbiologicbiologic markerbiological signal transductionbiomarkerblood-based biomarkerblood-based markerbody movementclinical interventionclinical therapyco-morbidco-morbiditycognitive dysfunctioncognitive functioncognitive losscohortcomorbidityconstrictioncontinuous monitoringdaily living functiondaily living functionalitydementia riskdemographicsdepressiondeprivationdigitaldigital datadigital markerdisparity in healthdrivingdriving behaviordrug/agentearly detectionexperienceexposomefine particlesfine particulate matterfunctional abilityfunctional capacitygene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkerglobal healthgreenspacehealth disparityhigh riskhuman old age (65+)improvedin vivolack of physical activitylate in lifelate lifelongitudinal, prospective studymalleable riskmodifiable riskmultidisciplinaryneural inflammationneurobehavioralneuroinflammationneuroinflammatorynormalityolder adultolder adulthoodontogenyover 65 yearsphysical inactivitypre-clinicalpreclinicalprimary degenerative dementiaprodromal ADprodromal Alzheimer'sprodromal Alzheimer's diseaseprospectivepublic health prioritiesracialracial backgroundracial originrecruitresponserisk factor for dementiarisk for dementiarural arearural dwellingrural householdsrural locationrural regionrural residencesedentarysenile dementia of the Alzheimer typesexsmart watchsmartwatchsocial culturesocial health determinantssocial rolesocial support networksocio-culturalsocioculturalspatial and temporalspatial temporalspatiotemporalstressorstructural determinantsstructural factorssuburbsuburbansuburbiatrial regimentrial treatmenturban areaurban environmenturban locationurban regionurban residenceurban setting≥65 years
Description preview
PROJECT SUMMARY/ABSTRACT
Alzheimer’s disease (AD) is a global public health priority as nearly 55 million of the world’s population
live with dementia, with cases projected to triple to 150 million by 2050. Dementia prevalence varies across
populations, and differences are due to complex relationships across demographic and social determinants of…
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