grant
Leveraging the GTP Biosynthetic Pathway for Anti-Tumor Therapies
Organization ROSWELL PARK CANCER INSTITUTE CORPLocation BUFFALO, UNITED STATESPosted 1 Dec 2025Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20262,3,7,8-Tetrachlorodibenzo-p-dioxin ReceptorsAH ReceptorsAdhesion PlaquesAffectAreaAryl Hydrocarbon ReceptorAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBiologyBreast CancerCancersCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCell membraneCell-Matrix Adherens JunctionsCellsCellular MigrationCellular MotilityChiro-InositolCytoplasmic MembraneDNA mutationDataDehydrogenasesDetectionDioxin ReceptorsDistantDrug TherapyElementsEnzyme GeneEnzymesFamilyFocal Adhesion Kinase 1Focal AdhesionsFocal ContactsG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGPCRGTPGTP PhosphohydrolasesGTP-Binding ProteinsGTP-Regulatory ProteinsGTPasesGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGuanosineGuanosine TriphosphateGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesIncidenceInositolIntermediary MetabolismIntracellular Communication and SignalingInvadedKruppel-like transcription factorsLesionMDA MB 231MDA-231MDA-MB231Malignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMediatingMediatorMembraneMesoinositolMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMetastatic breast cancerMolecularMonitorMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMotilityMutationNeoplasm MetastasisNuclear TranslocatorOncogenesisOncogenicOrganOxidoreductaseOxidoreductase GenePTK2 Protein Tyrosine Kinase 2Pathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalPlasma MembranePlayPolyaromatic Hydrocarbon ReceptorsPreventionProcessProductionProteinsRNA ExpressionReductasesRegulationReporterReportingResearchRoleSecondary NeoplasmSecondary TumorSignal TransductionSignal Transduction SystemsSignalingSiteSmall G-ProteinsSmall GTPasesStaining methodStainsStructureSupplementationTCDD ReceptorsTNBCTestingTherapeuticTherapeutic InterventionTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTumor CellTumor Cell InvasionTumor InvasionWorkbiological signal transductionbreast cancer progressioncancer cellcancer invasivenesscancer metastasiscancer progressioncancer typecell motilitydesigndesigningdrivingdrug interventiondrug treatmentendogenous substrate pp120experimentexperimental researchexperimental studyexperimentsezrinfocal adhesion kinasefocal adhesion protein tyrosine kinasefocal adhesion-associated protein tyrosine kinase pp125FAKgain of functiongenome mutationguanosinetriphosphataseimprovedin vivoinsightintervention therapyloss of functionmalignancymalignant breast tumormembrane structuremetastatic breast tumormetastatic mammary cancermetastatic mammary tumormortalityneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetparent grantpathwaypatient oriented outcomespharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphosphoprotein p81plasmalemmapreventpreventingprotein activationrho G-Proteinsrho GTP-Binding Proteinsrho GTPasesrho Protein P21rho Small GTP-Binding ProteinssensorshRNAshort hairpin RNAsmall hairpin RNAsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscription factortriple-negative breast cancertriple-negative invasive breast carcinomatumortumor cell metastasistumor growthtumor progressiontumorigenesisvirtual
Description preview
PROJECT ABSTRACT/SUMMARY (From the Parent Grant)
Invasion is one of the most detrimental features of all cancers, including breast cancer, as it allows cells to
escape the primary site and form metastases at distant organs. Despite progress in prevention and early
lesions detection, the mortality associated with metastatic breast cancer is still…
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