grant
Leveraging Large Language Models for the Design of Monoclonal Antibodies Against Malaria
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AI language modelsAnti-EGFR Monoclonal AntibodyAnti-Epidermal Growth Factor Receptor Monoclonal AntibodyAntibody ResponseAntigenic DeterminantsAntigensApplications GrantsAreaAssayAwardBindingBinding DeterminantsBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood erythrocyteBlood reticulocyteBone MarrowBone Marrow Reticuloendothelial SystemCambodiaCancer TreatmentCetuximabClinicalClinical Treatment MoabCollaborationsCulicidaeDevelopmentDiffusely basophilic erythrocyteDimensionsDiseaseDisorderEGF ReceptorEGFRERBB ProteinEast New GuineaEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEpitopesErythrocytesErythrocyticFundingGeneralized GrowthGenerationsGrant ProposalsGrowthHER1Hepatic CellsHepatic Parenchymal CellHepatocyteHu-mABsHumanIndividualInfectionInvadedKampucheaKhmer RepublicLaboratoriesLigandsLiverLiver CellsMAb TherapeuticsMadagascarMalagasy RepublicMalariaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMarrow erythrocyteMarrow reticulocyteMethodsMiceMice MammalsModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonoclonal AntibodiesMosquitoesMurineMusP vivaxP. vivaxPBMCPaludismPapua New GuineaParasitesPeripheral Blood Mononuclear CellPersonsPlasmodium InfectionsPlasmodium vivaxPlasmodium vivax MalariaPolychromatophilic ErythrocyteProductionProteinsRed Blood CellsRed CellRelapseReproducibility of FindingsReproducibility of ResultsReticulocytesRiskSeasonsSiteSporozoitesStructureTGF-alpha ReceptorTestingTherapeutic Monoclonal AntibodiesTimeTissue GrowthTransformer language modelTransforming Growth Factor alpha ReceptorTransmissionUniversitiesUrogastrone ReceptorVivax Malariaanti-cancer therapyapical membraneartificial intelligence language modelsblood corpusclesc-erbB-1c-erbB-1 Proteincancer therapycancer-directed therapyconformationconformationalconformational stateconformationallyconformationsdesigndesigningdevelopmentalerbB-1erbB-1 Proto-Oncogene ProteinerbBlhepatic body systemhepatic organ systemhumAbshuman mAbshuman monoclonal antibodieshuman monoclonalsimmunogenimmunogenicityimprovedin vitro testinglarge language modellarge scale language modelmAbsmassive scale language modelsmeetingmeetingsmodel designmonoclonal Absmonoclonal antibody drugsmurine mAbmurine monoclonal antibodynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenypreventpreventingproto-oncogene protein c-erbB-1scaffoldscaffoldingscreeningscreeningstherapeutic mAbstransmission process
Description preview
Project Summary - Current treatments for Pv are limited, highlighting the need for new therapies targeting
both liver and blood stages.
Relapsing parasites account for up to 80% of infections and disease, establishing
a global reservoir that is difficult to eliminate with current treatments. Blocking liver-stage infections is the most
effective…
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