grant
Leveraging Consanguinity in Pakistan to Uncover the Genomic Architecture of Alzheimer's Disease: Feasibility Study with ENIGMA-PAK
Organization PALO ALTO VETERANS INSTIT FOR RESEARCHLocation PALO ALTO, UNITED STATESPosted 15 Sept 2024Deadline 30 Jun 2027
NIHUS FederalResearch GrantFY202465 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAD related dementiaADRDAccountingAffectAgeAged 65 and OverAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAmericanArchitectureAwardBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceChinaCognitiveCollectionCommunitiesConsanguinityConsensusConsent DocumentsConsent FormsCountryDataData CollectionData Storage and RetrievalDementiaDeveloping CountriesDeveloping NationsDiagnosisDiagnosticEconomic IncomeEconomical IncomeElderlyEngineering / ArchitectureEnsureEthnic OriginEthnicityEuropeanFeasibility StudiesFemaleFloodingFloodsFollow-Up StudiesFollowup StudiesFundingGeneralized GrowthGeneticGenetic ResearchGenomeGenomicsGenotypeGoalsGrowthHandIncomeIndiaIndividualInformed Consent DocumentsInformed Consent FormsInfrastructureInternationalInvestigatorsKnowledgeLMICLearningLess-Developed CountriesLess-Developed NationsLightMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMainland ChinaMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiddle EasternNMR ImagingNMR TomographyNational Institute of AgingNational Institute on AgingNational Institutes of HealthNorth AfricanNorthern AfricanNuclear Magnetic Resonance ImagingOccidentalPakistanParticipantPatientsPersonsPhenotypePhotoradiationPilot ProjectsPopulationPopulation HeterogeneityPreparationPrimary Senile Degenerative DementiaProcessProtocolProtocols documentationProvinceRaceRacesResearchResearch PersonnelResearch ResourcesResearchersResourcesSamplingSecureShippingSiteSouth AsianThird-World CountriesThird-World NationsTissue GrowthTrainingTranslatingUnder-Developed CountriesUnder-Developed NationsUnited StatesUnited States National Institutes of HealthUniversitiesZeugmatographyabove age 65advanced ageafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaged ≥65agesaging populationcell repositorycellular repositorycognitive assessmentcognitive testingcohortcombatcommunicable disease transmissiondata acquisitiondata acquisitionsdata harmonizationdata retrievaldata storagedata storage sitedeveloping countrydeveloping nationdisease transmissiondiverse populationsexomeexomesexperiencegeriatrichandsharmonized dataheterogeneous populationhuman old age (65+)incomesinfectious disease transmissioninstrumentlow and middle-income countriesneural imagingneuro-imagingneuroimagingneurological imagingold ageontogenyover 65 yearsperi-urbanperiurbanphenotypic datapilot studypopulation agingpopulation diversitypreparationsprimary degenerative dementiaracialracial backgroundracial originsenile dementia of the Alzheimer typesenior citizensexwhite race≥65 years
Description preview
PROJECT SUMMARY/ABSTRACT
Currently, there are almost 55 million people living with dementia worldwide, and this number is estimated to
double every 20 years, reaching about 131.5 million in 2050. Most of the patients suffering from dementia (58%)
live in low- and middle-income countries (LMIC), with the fastest growth in the elderly population…
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