grant

Learning Related Plasticity in Mammalian Sound Localization Circuits

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Jan 2021Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20262-photon21+ years oldAblationAbscissionActive ListeningAddressAdultAdult HumanAnimalsAuditoryAuditory CortexAuditory LocalizationAuditory areaBackBehaviorBehavioralBinauralBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCodeCoding SystemConductive DeafnessConductive hearing lossCuesDataDorsumEarEarplugEncephalonEsthesiaExcisionExtirpationHeadHealthHearingHearing LossHumanHypoacusesHypoacusisImageImpairmentInferior ColliculusIntracellular Communication and SignalingJointsKnowledgeLearningLinkMapsMediatingMedical RehabilitationMiceMice MammalsModern ManMorphologyMurineMusNeocortexNerve CellsNerve UnitNeural CellNeurocyteNeuronsOwlsPathway interactionsPatternPeripheralPosterior Quadrigeminal BodyPrevalenceProcessRecoveryRecovery of FunctionRehabilitationRehabilitation therapyRemovalRewardsRoleSensationSensorySignal TransductionSignal Transduction SystemsSignalingSound LocalizationStreamStrigiformesSurgical RemovalTestingTimeTrainingTransmissionadaptive learningadult animaladulthoodauditory processingbinaural clustersbinaural hearingbiological signal transductiondeafdeafeneddysfunctional hearingflexibilityflexiblefunctional recoveryhearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthomotypical corteximagingimproved outcomeinsightisocortexlistening comprehensionlongitudinal imagingmature animalneopalliumneural circuitneural circuitryneurocircuitryneuronalnew approachesnovel approachesnovel strategiesnovel strategyoptogeneticspathwaypresynapticprofound hearing losspublic health relevancerehab therapyrehabilitativerehabilitative therapyresectionsegregationserial imagingsocial rolesoundsuccesssynaptic circuitsynaptic circuitrytransmission processtwo-photon
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Project Summary / Abstract
Binaural cues enable sound localization, which supports active listening by spatially segregating competing

sound streams. Consequently monaural hearing loss impairs sound localization and listening comprehension,

despite normal function in the spared ear. Encouragingly, humans and animals with monaural hearing loss can…

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