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Lactate production by tumor associated macrophages promotes tumorigenesis

Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AdoptedAnimalsAntibodiesAttenuatedB-Cell Stimulatory Factor 1 GeneBSF-1 GeneBSF1 GeneBacteriaBiochemicalBiochemical ProcessBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCancer TreatmentCancersCell BodyCellsDevelopmentE1A Binding Protein p300EP300EP300 geneEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExperimental Animal ModelGEM modelGEMM modelGene ExpressionGene TranscriptionGenesGeneticGenetic TranscriptionGenetically Engineered MouseGlycolysisGoalsHeterogeneityHistonesHumanHypoxiaHypoxicIL-13IL-4 GeneIL13IL4IL4 geneImmuneImmune responseImmunesIn VitroInflammatoryInterleukin-13Interleukin-4 GeneInterleukin-4 Precursor GeneKAT3BKnowledgeL-LysineLDH-ALDH-MLYT3LysineMacrophageMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMarrow monocyteMediatingMetabolicMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMitochondriaModelingModern ManModificationMolecularMolecular TargetMurineMusMyeloid CellsMφNatureNeoplasm MetastasisOncogenesisOxygen DeficiencyPathway interactionsPatientsPhasePhenotypePrevalenceProcessProductionPrognosisProteinsProteomicsPublishingRNA ExpressionRespirationRoleSecondary NeoplasmSecondary TumorStimulusT-Cell DepletionT-cell depletion therapyT-lymphocyte depletion therapyT8 CellsT8 LymphocytesTeff cellTestingTherapeuticTranscriptionTranslationsTumor ImmunityTumor PromotionTumor-associated macrophagesWorkadaptive immunityangiogenesisanti-canceranti-cancer therapeuticanti-cancer therapyanti-tumor immunityantitumor immunityattenuateattenuatescancer immunitycancer metastasiscancer microenvironmentcancer therapycancer-directed therapycytokinedevelopmentaleffector T cellepigeneticallyexperimentexperimental researchexperimental studyexperimentsgene functiongenetically engineered mouse modelgenetically engineered murine modelhistone acetyltransferase p300host responseimmune system responseimmunoresponseimprovedin vivoinsightlactate dehydrogenase Amalignancymitochondrialmonocyteneoplasm/cancernovelp300pathwaypromoterpromotorrespiratory mechanismsocial roletherapeutic targettranscriptomicstranslationtumortumor cell metastasistumor growthtumor microenvironmenttumorigenesis

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Description preview

ABSTRACT
Tumor-associated macrophages (TAMs) are the most prevalent immune cell in the tumor microenvironment.
TAMs adopt an M2-like phenotype that supports angiogenesis, attenuates anti-cancer immune responses, and
facilitates metastatic dissemination. Studies in humans and experimental animal models support targeting
TAMs for anti-cancer…

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Lactate production by tumor associated macrophages promotes tumorigenesis β€” UNIVERSITY OF CHICAGO | UNITED STATES | Mar | Dev Procure