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Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial design

Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Dec 2023Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025Active Follow-upAcuteAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoplexyBiologicalBlood PlateletsBlood PressureBrain TIABrain Vascular AccidentCephalicCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCharacteristicsCholesterolClinicalClinical TreatmentClinical TrialsClinical Trials DesignColchicineCommon Data ElementCranialDataData BasesData ElementData SetDatabasesDiabetes MellitusDiseaseDisease-Free SurvivalDisorderDrugsEventEvent-Free SurvivalFutureGoalsIndividualInterventionIntracranial AtherosclerosisIntracranial Atherosclerotic DiseaseIschemiaIschemic StrokeKineticsMapsMarrow plateletMathMathematicsMedicationMedicineMinorModelingOutcome MeasurePathological ConstrictionPatient riskPatientsPharmaceutical PreparationsPhasePlateletsPrevention trialPreventive MedicineProbabilistic ModelsProbability ModelsProcessRadiographyRandomizedRecoveryRecurrenceRecurrentRegression AnalysesRegression AnalysisRegression DiagnosticsResearchRiskRisk FactorsRoentgenographySecondary PreventionSmoking StatusStandardizationStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStatistical ModelsStatistical RegressionStenosisStrokeStroke preventionStructureTestingTherapeutic InterventionThrombocytesTimeTransient Ischemic Attackactive followupactive methodactive techniqueactive treatmentacute cerebrovascular accidentacute strokeafter strokebiologicbrain attackcerebral vascular accidentcerebrovascular accidentclinical interventionclinical therapycomputer based predictiondata basedata dictionarydata harmonizationdata standardizationdata standardsdesigndesigningdiabetesdrug/agentefficacy outcomesexperiencefallsfollow upfollow-upfollowed upfollowupharmonized dataindexinginsightinterestintervention therapyintracranial arterykinetic modellarge data setslarge datasetsmeasurable outcomemini strokemini-strokeoutcome measurementpost strokepoststrokepredictive modelingpreventprevent strokepreventative medicinepreventingradiological imagingrandomisationrandomizationrandomly assignedresponserisk for strokerisk of strokesafety outcomessecondary analysisstatistical analysisstatistical linear mixed modelsstatistical linear modelsstroke modelstroke patientstroke riskstrokedstrokestherapeutic agent developmenttherapeutic developmenttrial designtrial regimentrial treatment

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Project Summary
Recent clinical trials of platelet-inhibiting medications for preventing a second stroke following an initial minor
stroke or transient ischemic attack (TIA) have shown that recurrences of strokes over time follow a distinct time
course, with a high rate of recurrence over the first few days, slowing to a steady lower rate over…

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Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial desig | Dev Procure