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Kappa opioid and oxytocin interactions in social buffering and separation

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Apr 2021Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAcuteAddressAdultAdult HumanApoplexyBehavioralBiologicalBrainBrain Nervous SystemBrain Vascular AccidentBuffersCallicebusCallicebus cupreusCardiovascular DiseasesCausalityCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicCommon Rat StrainsCoppery Titi MonkeyDistressDown-RegulationDrug TherapyDrugsEncephalonEndocrine Gland SecretionEtiologyExhibitsFemaleHealthHealth behaviorHormonalHormonesHumanHypothalamic structureHypothalamusImageIndividualLaboratoriesLeadM mulattaM. mulattaMacaca mulattaMacaca rhesusMedicationMental disordersMental health disordersMiceMice MammalsModelingModern ManMurineMusNHP modelsNeurobiologyNucleus AccumbensOcytocinOpiatesOpioidOxytocinPETPET ScanPET imagingPETSCANPETTPair BondPartner in relationshipPb elementPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysical distancingPlecturocebus cupreusPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimatesPrimates MammalsPsychiatric DiseasePsychiatric DisorderRad.-PETRatRats MammalsRattusRecombinant OxytocinRhesus MacaqueRhesus MonkeyRiskRoleSocial DistanceStressStrokeSystemTestingTherapeutic Hormoneacute stressadulthoodbiologicbiological adaptation to stressbrain attackcardiovascular disordercausationcerebral vascular accidentcerebrovascular accidentcoppery titidiet and exercisedisease causationdrug interventiondrug treatmentdrug/agentdysphoriahealth related behaviorheavy metal Pbheavy metal leadhypothalamicimagingimprovedkappa opiatekappa opioidkappa opioid receptorskappa receptorsmalematemental illnessmortalityneurobiologicalneurobiological mechanismnonhuman primate modelspharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypreferencepsychiatric illnesspsychological disorderreaction; crisisreceptor bindingreceptor boundresponsesocialsocial attachmentsocial bondingsocial relationshipssocial rolesocial separationsocial stresssocially stressedstress bufferingstress managementstress responsestress; reactionstressorstrokedstrokessurvivorshiptiti monkeyκ opiateκ opioidκ opioid receptorsκ receptorκ-ORκOR

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Description preview

Project abstract Social connectedness is crucially important to human health, and is increasingly
recognized as such, especially in these days of “social distancing”. While strong social relationships may

confer a survivorship advantage with large effect sizes similar to those for health behaviors like diet and

exercise1, disruption and loss of…

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Kappa opioid and oxytocin interactions in social buffering and separation — UNIVERSITY OF CALIFORNIA AT DAVIS | UNITED S | Dev Procure