grant
Ion Channel Transporter Interactions
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Feb 2019Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AchlorhydriaAchylia GastricaAddressArrhythmiaAtaxiaAtaxyAwardBiochemicalBiologyBody TissuesBrainBrain Nervous SystemCardiac ArrhythmiaCell Communication and SignalingCell SignalingCell membraneChargeCommon Rat StrainsComplexCoordination ImpairmentCoupledCytoplasmic MembraneDataDiabetes MellitusDiseaseDisorderDysfunctionDyssynergiaElectrophysiologyElectrophysiology (science)EncephalonEpilepsyEpileptic SeizuresEpilepticsEpisodic ataxiaFamilyFunctional disorderGoalsHealthHeart ArrhythmiasHydrogen OxideHypertensionHypothyroidismIn vivo analysisInflammationIntracellular Communication and SignalingIon ChannelIonic ChannelsIonsK elementKnock-outKnockoutKnowledgeLinkMembrane ChannelsMolecularMovementNa elementNerve Transmitter SubstancesNeurophysiology / ElectrophysiologyNeurotransmittersPainPainfulPhysiopathologyPlant ExtractsPlant derived metabolitesPlantsPlasma MembranePotassiumProcessProtein-Binding RadioassayProteinsRadioligand AssayRadioreceptor AssayRatRats MammalsRattusRegulationResearchRodentRodentiaRodents MammalsRoleScreening ResultSeizure DisorderSignal TransductionSignal Transduction SystemsSignalingSodiumStructureTechniquesTherapeuticTissuesTransgenic OrganismsVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderVitaminsWaterWorkbasebasesbiological signal transductionbody movementdiabeteselectrophysiologicalepilepsiaepileptogenicexperiencefield based datafield learningfield studyfield testgastric anacidityhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimage-based methodimaging methodimaging modalityin vivoin vivo evaluationin vivo testingmouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologyplant metabolitesplasmalemmasmall moleculesocial rolesolutesugartranscriptomicstransgenicvoltage
Description preview
Project Summary
Voltage-gated potassium (Kv) channels, essential for cellular electrical activity, are generated by tetramers of
pore-forming α subunits, often in complexes with other, non-pore-forming β subunits and other protein classes.
Sodium-coupled solute transporters provide a mechanism for transport of water-soluble ions,…
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