grant
Ion Channel Pharmacology for Pain and Epilepsy
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 May 2022Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY2026AccidentsAction PotentialsAmmon HornAtaxiaAtaxyBehaviorCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsClinicalComplexCoordination ImpairmentCornu AmmonisDependenceDiseaseDisorderDrug TargetingDysfunctionDyssynergiaElementsEpilepsyEpileptic SeizuresEpilepticsFoundationsFunctional disorderGoalsGrantHippocampusIndividualIon ChannelIonic ChannelsK channelKnowledgeLaboratoriesMedulla SpinalisMembrane ChannelsMembrane PotentialsMotor CellMotor NeuronsNerve CellsNerve UnitNervous System PhysiologyNeural CellNeurocyteNeurologic functionNeurological functionNeuronsNociceptorsPainPainfulPatternPeptidesPharmacologyPhysiopathologyPopulationPotassium ChannelPotassium Ion ChannelsPyramidal neuronResearchResting PotentialsRoleSeizure DisorderShapesSodium ChannelSodium Ion ChannelsSpinal CordToxinTransmembrane PotentialsVDCCVoltage-Dependent Calcium ChannelsWorkcell typedesigndesigningdifferential expressiondifferentially expresseddrug actionepilepsiaepileptogenicexperiencehippocampalhippocampal pyramidal neuroninterestmotoneuronnervous system functionneuronalneuronal patterningnociceptive neuronsnovelpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspathophysiologypharmacologicpreservationrational designsmall moleculesocial roletargeted agenttranscriptional differencesvoltage
Description preview
Project Summary/ Abstract
The proposed work will integrate two long-standing lines of research in the laboratory. One is to
understand is to understand how the many types of ion channels present in a single neuron
work together to regulate its firing pattern. In earlier grant periods, we focused on the individual
gating behavior and functional…
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