grant
Involvement of dopamine signaling in chronic pain-induced negative affective state and nicotine use comorbidity
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAffectiveAffective DisordersAffective SymptomsAnabolismAnalgesia TestsAnhedoniaAnimalsAnxietyAssayAttenuatedBehaviorBehavioralBindingBioassayBiological AssayBrainBrain Nervous SystemCell Communication and SignalingCell SignalingChronic intense painCognitive ManifestationsCognitive SymptomsCommon Rat StrainsCorpus StriatumCorpus striatum structureCyclicityD(2) Dopamine Receptor GeneD2 receptorD2DRD2DR GeneD2RD2R GeneDA NeuronDRD2DRD2 ReceptorDRD2 geneDataDevelopmentDimensionsDiseaseDisorderDopamineDopamine AntagonistsDopamine D2 ReceptorDopamine Receptor AntagonistsDopamine Receptor D2 GeneDopamine neuronDopaminergic AntagonistsEducational workshopEncephalonGoalsHealth CareHealth Care CostsHealth CostsHistoryHumanHydroxytyramineIndividualInfumorphInfusionInfusion proceduresIntakeInterventionIntracellular Communication and SignalingIntravenousInvestigationKadianKnowledgeMS ContinMSirMaintenanceMeasuresMediatingMediationMental DepressionMentorsModelingModern ManMolecular InteractionMood DisordersMorphiaMorphineMotivationNegotiatingNegotiationNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurobiologyNicotineNicotine DependenceNicotine Use DisorderNociception TestsNucleus AccumbensOramorphOramorph SRPainPain AssessmentPain MeasurementPain measurePainfulPathway interactionsPatientsPeriodicityPre-Clinical ModelPreclinical ModelsPrincipal InvestigatorProductivityPsychiatryPsychological reinforcementPublic HealthRatRats MammalsRattusRecording of previous eventsReinforcementReportingResearchRewardsRhythmicityRiskRisk FactorsRoxanolScanningScientistSelf AdministeredSelf AdministrationSensorySignal TransductionSignal Transduction SystemsSignalingSmokingStatex SRStriate BodyStriatumSubstance abuse problemTechnical ExpertiseTherapeutic InterventionTobacco ConsumptionTobacco useTrainingVentral Tegmental AreaWorkWorkshopabuse liabilityabuse of substancesabuse potentialadulthoodanxiety-like behaviorattenuateattenuatesbiological signal transductionbiosynthesiscareerchronic painchronic pain patientco-morbidco-morbiditycomorbidityconferenceconventiondepressiondevelopmentaldiversity and inclusiondiversity and inclusivitydopaminergic neurondrug reinforcementexperienceexposure to nicotineextracellularfaculty mentorhigh rewardhistorieshuman datain vivoindividualized therapeuticinfusionsinsightintervention therapyjob environmentnegative affectnegative affectivityneural controlneural regulationneurobehavioral symptomneurobiologicalneurobiological mechanismneurochemicalneurochemistryneuromodulationneuromodulatoryneuronal circuitneuronal circuitryneuroregulationnicotine addictionnicotine consumptionnicotine dependentnicotine exposurenicotine self-administrationnicotine useoptogeneticspain assaypain sensitivitypathwaypatient with chronic painpersonalized therapeuticpharmacologicprofessional atmosphereprogramsreward circuitrystriatalsubstance abusesummitsymposiasymposiumtechnical skillstherapeutic agent developmenttherapeutic developmenttobacco product usevapingventral tegmentumwork atmospherework environmentworkplace climateworkplace environment
Description preview
Project Summary/Abstract
Nicotine addiction among individuals with chronic pain is a serious public health concern with significant health-
care expenses and lost productivity. Chronic pain-associated negative affective state, such as anxiety, is a risk
factor for tobacco use. Greater chronic pain intensity increases sensitivity to anxiety, which…
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