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Investigations of antiretroviral therapy penetration in cerebrospinal fluid
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 5 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AACTGACTGAIDS VirusAIDS clinical trial groupAIDS dementiaAIDS with dementiaAIDS-related dementiaAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immune Deficiency Syndrome related dementiaAcquired Immunodeficiency Syndrome VirusAddressAgeAgreementAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAnti-Retroviral AgentsAssayAwardB-Cell Differentiation Factor GeneB-Cell Stimulatory Factor 2 GeneBBB crossingBSF-2 GeneBSF2 GeneBasic ResearchBasic ScienceBeta-2 Gene InterferonBioassayBiological AssayBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemCCL2CCL2 geneCNS Nervous SystemCell modelCellular modelCentral Nervous SystemCerebrospinal FluidCharacteristicsChemokine, CC Motif, Ligand 2ClinicalClinical PharmacologyClinical ResearchClinical StudyCohort StudiesConcurrent StudiesDataDementia Due to HIV DiseaseDementia associated with AIDSDementia in human immunodeficiency virus (HIV) diseaseDetectionDevelopmentDiscipline of NursingDoctor of PhilosophyDrug ExposureDrug KineticsDrug usageDrugsDysfunctionEXTMREncephalonEnsureEthicsExcretory functionExposure toExtramuralExtramural ActivitiesFacultyFunctional disorderFundingFutureGoalsHIVHIV 1 associated neurocognitive disorderHIV DementiaHIV InfectionsHIV associated dementiaHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV-1 associated dementiaHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-1 dementiaHIV-associated neurocognitive disorderHIV-related dementiaHSF GeneHTLV-III InfectionsHTLV-III-LAV InfectionsHandHepatocyte Stimulatory Factor GeneHumanHuman FigureHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman bodyHybridoma Growth Factor GeneIFNB2 GeneIL-6 GeneIL6IL6 geneIQ DeficitImmune responseIn VitroIndividualInstitutionInterleukin 6 (Interferon, Beta 2) GeneInterleukin-6 GeneIntermediary MetabolismInvestigationInvestigatorsK23 AwardK23 MechanismK23 ProgramLAV-HTLV-IIILife ExpectancyLinkLiquid substanceLiteratureLymphadenopathy-Associated VirusMCAFMCP-1MCP1MeasuresMedical centerMedicationMental disordersMental health disordersMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMetabolic ProcessesMetabolismMissionModern ManMonkeysMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JENIMHNamesNational Institute of Mental HealthNational Institutes of HealthNebraskaNeopterinNeuraxisNeurocognitiveNeurocognitive DeficitNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurologicNeurologicalNon-Polyadenylated RNANursingNursing FieldNursing ProfessionPK/PDParticipantPathogenesisPathway interactionsPatientsPenetrationPerformancePersonsPh.D.PhDPharmaceutical PreparationsPharmacokineticsPharmacologyPhysiologicPhysiologicalPhysiopathologyPlasmaPlasma SerumPopulationPreventionPrimatesPrimates MammalsPrincipal InvestigatorProductivityPropertyPsychiatric DiseasePsychiatric DisorderR-Series Research ProjectsR01 MechanismR01 ProgramRNARNA Gene ProductsRecoveryRegimenReportingResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ProposalsResearchersReticuloendothelial System, Serum, PlasmaRibonucleic AcidSCYA2SIVSamplingScholars ProgramScientistSeveritiesSimian Immunodeficiency VirusesSmall Inducible Cytokine A2StructureTechniquesTestingTherapeuticTissue SampleTissuesTrainingTranslational ResearchTranslational ScienceTranslationsUnited States National Institutes of HealthUniversitiesViralViral BurdenViral LoadViral Load resultViral reservoirVirusVirus reservoirVirus-HIVWorkabsorptionacquired immunodeficiency syndrome clinical trial groupagesanti-retroviralantiretroviral therapyantiretroviral treatmentblood-brain barrier crossingbloodbrain barrier crossingbrain endothelial cellbrain microvascular endothelial cellbrain vascular endothelial cellcareercareer developmentcerebral endothelial cellcerebral microvascular endothelial cellcerebral spinal fluidcerebral vascular endothelial cellclinical significanceclinical translationclinically significantclinically translatableco-infectionco-morbidco-morbiditycohortcoinfectioncollegecollegiatecomorbiditydesigndesigningdevelopmentaldidactic curriculumdidactic educationdrug usedrug/agentelderly patientethicalexcretionexperimentexperimental researchexperimental studyexperimentsfluidhandshigh riskhost responseimmune system responseimmunoresponseimprovedin vitro Modelin vivoinnovateinnovationinnovativeintelligence quotient deficitinter-patient variabilityinterpatient variabilityliquidmembermemory CD4 T cellmemory CD4 T lymphocytemental illnessmodel of animalmonolayermultidisciplinarynamenamednamingneural inflammationneurocognitive declineneurocognitive impairmentneuroinflammationneuroinflammatorynew approachesnovelnovel approachesnovel strategiesnovel strategyolder patientoptimal therapiesoptimal treatmentspathophysiologypathwaypatient oriented researchpatient oriented studypatient variabilitypatient variationpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpharmacokinetic modelpharmacokinetics and pharmacodynamicspharmacologicprofessorprogramsprospectivepsychiatric illnesspsychological disorderresponseresponsible research conductskill acquisitionskill developmentsoundspinal fluidtranslationtranslation researchtranslational investigationtranslational investigatortranslational researchertranslational scientistvariability between patientsvariation between patients
Applications closed.
Description preview
Name of Principal Investigator: Sean N. Avedissian
Project Summary
I am applying for a Mentored Patient-Oriented Research Career Development Award (NIMH-K23) for training in patient-
oriented research with the goal of development into a productive and independent clinical and translational researcher. As
part of this award, I will complete a PhD…
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