grant
Investigating Transplacental Immune Pathways Contributing to Fetal Brain Pathology in Maternal Influenza
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 10 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025ASDAutismAutistic DisorderB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BehaviorBlocking AntibodiesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBlood leukocyteBrainBrain Nervous SystemBrain PathologyCausalityCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCells Placenta-TissueCellular FunctionCellular PhysiologyCellular ProcessClinicalDependenceDeveloping fetusDevelopmentDiseaseDisorderDrugsEarly Infantile AutismEncephalonEtiologyExposure toFatality rateFetal DevelopmentFetal Growth RestrictionFetal Growth RetardationFetusFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGeneticGestationGoalsGrippeHPGFHealthHematogenousHepatocyte-Stimulating FactorHortega cellHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinIUGRImmuneImmune Cell ActivationImmune responseImmune signalingImmunesImmunocompetentIncidenceIndividualInfantile AutismInfectionInfiltrationInflammationInflammatoryInfluenzaInfluenza AInfluenza A virusInfluenza VirusInfluenza Viruses Type AInfluenzavirus AInterleukin-6InterventionIntracellular Communication and SignalingIntrauterine Growth RetardationKO miceKanner's SyndromeKnock-out MiceKnockout MiceLeucocytic infiltrateLeukocytesLeukocytes Reticuloendothelial SystemLifelong disabilityLymphocytic InfiltrateMGI-2MacrophageMarrow NeutrophilMarrow leukocyteMaternal-Fetal ExchangeMedicationMicrogliaModelingMolecularMothersMouse StrainsMyeloid Differentiation-Inducing ProteinMφNeurodevelopmental DisorderNeuroimmuneNeurological Development DisorderNeuronal DifferentiationNeutrophilic GranulocyteNeutrophilic LeukocyteNormal PlacentomaNull MouseOrthomyxovirus Type AOutcomePathway interactionsPatternPermanent disabilityPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPlacentaPlacenta Embryonic TissuePlacentomePlasmacytoma Growth FactorPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPregnancyPregnant WomenPremature BirthPrematurely deliveringPreterm BirthProductionProliferatingProteinsRecombinant CytokinesRiskRisk FactorsRodent ModelRoleSchizophreniaSchizophrenic DisordersSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSterilitySubcellular ProcessT cell infiltrationTechniquesTeff cellTeratogenicTeratogenicityTeratogensTestingTimeTransplacental ExposureType A InfluenzaVascular PermeabilitiesViralViral DiseasesVirusVirus DiseasesWhite Blood CellsWhite CellWorkantenatalantepartumautism spectral disorderautism spectrum disorderautistic spectrum disorderbiological signal transductionbrain deformitybrain malformationcausationcongenital brain anomalycongenital brain deformitycytokinecytokine based immunotherapycytokine based therapycytokine immunotherapycytokine therapycytokine treatmentdementia praecoxdevelopmentaldisease causationdrug/agenteffector T cellexpectant motherexpectant womenexpecting motherexpecting womenexperienceexperimentexperimental researchexperimental studyexperimentsexposed in uterofetalfetal exposureflow cytophotometryflu infectionflu outbreakflu virus infectiongitter cellhospitalization rateshost responseimmune activationimmune competentimmune system responseimmunoresponseimpaired fetal growthimprovedin uteroin utero exposurein vivoindividuals who are pregnantinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinflammatory environmentinflammatory milieuinfluenza infectioninfluenza outbreakinfluenza virus infectioninfluenzavirusinhibitorinsightinterferon beta 2intra-uterine environmental exposureintra-uterine growth restrictionintra-uterine growth retardationintrauterine environmental exposureintrauterine growth restrictionmaternal riskmaternal-fetal interfacemesogliamicroglial cellmicrogliocytemigrationmouse modelmurine modelneural inflammationneurodevelopmental diseaseneuroinflammationneuroinflammatoryneutrophiloffspringpandemic viruspathogenpathwaypeople who are pregnantperivascular glial cellpregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliveryprenatal exposureprenatal growth disorderprenatally exposedpreterm deliveryrecruitrespiratoryresponseschizophrenicseasonal fluseasonal influenzasocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssterilestillbirthstillbornthose who are pregnantvascularviral disease outbreakviral infectionviral outbreakviral pandemicvirus disease outbreakvirus infectionvirus-induced diseasewhite blood cellwhite blood corpusclewomen who are pregnant
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Project Summary/Abstract
The overarching goal of this application is to identify targetable transplacental immune signaling pathways for
optimizing antenatal therapies that improve maternal and offspring health outcomes during seasonal influenza
outbreaks. Influenza viruses pose ever-present threats to the health of pregnant women and escalate the…
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