grant
Investigating the role of tumor-intrinsic BCAT1 in HCC growth and anti-tumor immunity
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20252-ketoglutarate2-oxoglutarateAffectAmino Acid ChannelAmino Acid Transport SystemsAmino Acid TransporterAntigensApoptosisApoptosis PathwayBlood SerumBranched-Chain Amino AcidsC57BL/6 MouseCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancer CauseCancer EtiologyCancer TreatmentCancersCarcinoma CellCatabolismCell BodyCell Communication and SignalingCell CycleCell Division CycleCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular ExpansionCellular FunctionCellular GrowthCellular Immune FunctionCellular Metabolic ProcessCellular PhysiologyCellular ProcessCessation of lifeChronicClinicalClinical ResearchClinical StudyConsumptionDENADNA mutationDataDeathDependenceDiagnosisDietDiethylnitrosamineEnzyme GeneEnzymesEssential Amino AcidsFibrosisFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGlutamatesGrowthHCC cellHCC cell lineHepatic CancerHepatic CellsHepatic Parenchymal CellHepatocarcinogenesisHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHeterogeneityHigh Fat DietHistologyHumanHuman Cell LineImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune ToleranceImmune infiltratesImmune mediated therapyImmunesImmunologic DiseasesImmunologic ToleranceImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyIn VitroIncidenceInflammationInflammatoryInjectionsIntracellular Communication and SignalingIsoleucineIsotopesKeto AcidsL-GlutamateL-ValineLabelLeucineLiverLiver CarcinogenesisLiver CellsLiver Cells CarcinomaMAFLDMalignant CellMalignant Epithelial CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMetabolicMetabolic DiseasesMetabolic DisorderMetabolic PathwayMiceMice MammalsModern ManMorphologyMurineMusMutationN,N-diethylnitrosamineN-NitrosodiethylamineN-diethylnitrosamineN-ethyl-N-nitroso-ethanamineNDEANatural regenerationNitrosodiethylamineNon obeseNonobeseNucleotide SynthesisOncogenesisOncogenicPathway interactionsPatientsPhenotypePlasmidsPopulationPrimary carcinoma of the liver cellsProcessProductionProgrammed Cell DeathProtein BiosynthesisProteinsPurines/Pyrimidines/Nucleotides/Nucleic Acids MetabolismRationalizationReactionRegenerationRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRisk FactorsRoleSCID MiceSerumSevere Combined Immunodeficient MiceSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStrains Cell LinesSubcellular ProcessSupplementationT8 CellsT8 LymphocytesTCGATailTestingThe Cancer Genome AtlasThesaurismosisTissue GrowthTumor CellTumor ImmunityTumor PromotionUpregulationValineVeinsViral hepatitisWorkalpha ketoglutarateamino groupanti-cancer therapyanti-tumor immunityantitumor immunitybiological signal transductionbioluminescence imagingbioluminescent imagingbranched amino acidsbranched chain amino acid aminotransferasebranched-chain L-amino-acid aminotransferasebranched-chain aminotransferasesbranched-chain-amino-acid transaminaseburden of diseaseburden of illnesscancer cellcancer immunitycancer microenvironmentcancer therapycancer typecancer-directed therapycarcinogenesis in the livercell growthcell metabolismcellular metabaolismchronic liver injurycultured cell linecytokinediabeticdietarydietsdisease burdenflow cytophotometrygenome mutationglutamate-branched chain amino acid transaminaseglutamatergichepatic body systemhepatic carcinogenesishepatic organ systemhepatitis virus infectionhepatocellular carcinogenesishepatocellular carcinoma cell lineimmune cell infiltrateimmune drugsimmune functionimmune system toleranceimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune unresponsivenessimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunogenicityimmunologic therapeuticsimmunological paralysisimmunotherapeuticsimmunotherapy agentimprovedin vivoin vivo Modelinsightketoacidknock-downknockdownliver cancerliver cancer pathogenesisliver carcinomaliver malignancyliver tumorigenesismalignancymalignant liver tumormembermetabolic-associated fatty liver diseasemetabolism disorderneoplasm/cancerneoplastic cellnucleotide metabolismontogenyoverexpressoverexpressionpathwaypatient responsepatient specific responseproliferation capabilityproliferation capacityproliferation potentialproliferative capabilityproliferative capacityproliferative potentialprotein expressionprotein synthesisregenerateresistance to therapyresistant to therapyresponseresponsive patientscRNA sequencingscRNA-seqshRNAshort hairpin RNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall hairpin RNAsocial roletherapeutic resistancetherapy resistanttransaminase Btransaminationtreatment resistancetumortumor growthtumor microenvironmenttumorigenesisuptakeα-ketoglutarateα-oxoglutarateαKG
Description preview
PROJECT SUMMARY
Hepatocellular carcinoma (HCC) is the predominant subtype of liver cancer and arises almost exclusively in the
context of chronic inflammation. The healthy liver is a modulator of systemic immune tolerance, recognizing
harmless dietary and environmental antigens from the gut and degrading them without inducing inflammation.…
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