grant
Investigating the Role of Slc4a4 in Multiple Sclerosis
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 28 Jul 2025Deadline 27 Jul 2028
NIHUS FederalResearch GrantFY2025AD dementiaAcquired brain injuryAddressAdventitial CellAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaApoplexyAssayAstrocytesAstrocytusAstrogliaAutoimmune DiseasesAutoregulationBBB disruptionBBB functionBBB permeabilizationBBB permeableBioassayBiological AssayBlood - brain barrier anatomyBlood ProteinsBlood brain barrier dysfunctionBlood capillariesBlood-Brain BarrierBody TissuesBrain InjuriesBrain Vascular AccidentCNS DiseasesCNS Nervous SystemCNS disorderCandidate Disease GeneCandidate GeneCell BodyCell CommunicationCell InteractionCell LineCell-to-Cell InteractionCellLineCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicalCognitive deficitsDataDemyelinationsDiseaseDisease ProgressionDisorderDisseminated SclerosisDysfunctionEAEEctopic ExpressionEndothelial CellsEndothelinEndothelin ReceptorEndotheliumEndothelium-Derived Vasoconstrictor Factor ReceptorsEndothelium-Derived Vasoconstrictor FactorsExhibitsExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExtravasationFunctional disorderGenesGeneticHemato-Encephalic BarrierHomeostasisHumanImmuneImmune infiltratesImmunesImpairmentInfiltrationInflammationInflammatoryIntermediary MetabolismIntrathecal InjectionsIonsKO miceKnock-out MiceKnockout MiceKnowledgeLeakageMS LesionsMedulla SpinalisMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManMolecularMotorMultiple SclerosisMultiple Sclerosis LesionsMurineMusMyelinNa-HCO3 SymportNerve Transmitter SubstancesNervous System DiseasesNervous System DisorderNeuraxisNeurologic DeficitNeurologic DisordersNeurological DisordersNeurotransmittersNull MouseOccluding JunctionsPathogenesisPathologicPathologyPathway interactionsPeptidesPericapillary CellPericytesPerivascular CellPermeabilityPersonsPhenotypePhysiological HomeostasisPhysiopathologyPlayPre-Clinical ModelPreclinical ModelsPrimary Senile Degenerative DementiaRNA SeqRNA sequencingRNAseqReceptor ProteinRecoveryRegulationRoleRouget CellsSamplingSensorySeverity of illnessSodium Bicarbonate SymportSodium-Bicarbonate CotransporterSodium-Bicarbonate SymportersSpillageSpinal CordStrains Cell LinesStrokeStructureSymptomsTestingTherapeuticTight JunctionsTissuesVirusWild Type MouseZonula Occludensastrocytic gliaautoimmune conditionautoimmune disorderautoimmune encephalomyelitisautoimmunity diseaseaxonal degenerationblood-brain barrier disruptionblood-brain barrier functionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier disruptionbloodbrain barrier functionbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain attackbrain damagebrain-injuredcapillarycell typecerebral vascular accidentcerebrovascular accidentcognitive defectsconditional knock-outconditional knockoutcultured cell linedegenerative axondemyelinatedisease severityendothelial dysfunctiongain of functionimmune cell infiltrateimprovedinsular sclerosismolecular transportermouse modelmurine modelneurological diseasenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionpathophysiologypathwaypharmacologicpreventpreventingprimary degenerative dementiareceptorsenile dementia of the Alzheimer typesocial rolestrokedstrokestranscriptome sequencingtranscriptomic sequencingtranscriptomicswastingwildtype mouse
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ABSTRACT
Multiple Sclerosis (MS) is one of the most common autoimmune diseases affecting the central nervous system,
impacting approximately 2.5 million people worldwide. It is characterized by immune cell-driven inflammatory
demyelination and axonal degeneration, leading to a spectrum of motor, sensory, and cognitive deficits. A key
pathological…
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