grant
Investigating the Role of S. aureus Citrate Metabolism in Prosthetic Joint Infection
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Anti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsArthroplastyBacteriaBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood granulocytic cellBlood leukocyteCSIFCSIF-10Cell BodyCell-Extracellular MatrixCellsChronicCitratesCitric Acid CycleClinicalComplexComplicationCytokine Synthesis Inhibitory FactorDataDevelopmentECMEarly InterventionEnzyme GeneEnzymesExposure toExtracellular MatrixFellowshipFormatesFutureGene ExpressionGene TranscriptionGenesGenetic TranscriptionGranular LeukocytesGranulocytic cellHDAC11HDAC11 geneHistone Deacetylase 11HumanIL-10IL10IL10AImmuneImmune Cell ActivationImmune EvasionImmune infiltratesImmune responseImmunesInfectionInfectious Skin DiseasesInflammation MediatorsInterleukin 10 PrecursorInterleukin-10Intermediary MetabolismInterventionJoint Prosthesis ImplantationKrebs CycleLaboratoriesLeucocytic infiltrateLeukocytesLeukocytes Reticuloendothelial SystemLibrariesLinkLong-term infectionMRSAMacrophageMarrow NeutrophilMarrow leukocyteMetabolicMetabolic ProcessesMetabolismMethicillin Resistant S. AureusMicrobial BiofilmsMiscellaneous AntibioticModelingModern ManMorbidityMyeloid-derived suppressor cellsMφNebraskaNeutrophilic GranulocyteNeutrophilic LeukocytePathogenesisPathogenicityPatientsPeriprosthetic joint infectionPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulation HeterogeneityPredispositionProcessProductionPropertyProsthesisProsthetic deviceProstheticsRNA ExpressionRegulationReplacement ArthroplastyReporterReporter GenesResearchResistance to antibioticsResistant to antibioticsRoleS aureusS. aureusShapesSoft Tissue InfectionsStaph aureusStaphylococcus aureusStructureSusceptibilityTCA cycleTranscriptionTricarboxylic Acid CycleWhite Blood CellsWhite CellWorkalternative treatmentanti-microbialantibiotic drug resistanceantibiotic resistantantibiotic toleranceantimicrobialbacteria metabolismbacterial metabolismbiofilmchronic infectioncutaneous infectiondevelopmentaldiverse populationsexperimentexperimental researchexperimental studyexperimentsflexibilityflexibleglobal gene expressionglobal transcription profilegranulocyteheterogeneous populationhost responseimmune activationimmune cell infiltrateimmune evasiveimmune system responseimmunoresponseimmunosuppressive myeloid cellsin vivoinfected skininflammatory mediatorinsightjoint arthroplastyjoint replacementmethicillin resistance Staphylococcus aureusmethicillin resistant Staphylococcus aureusmethicillin resistant strains of Staphylococcus aureusmortalitymouse modelmurine modelmutantmyeloid suppressor cellsmyeloid-derived suppressive cellsneutrophilnovelpersistent infectionpopulation diversitypressureprosthetic joint infectionresistance strainresistant strainresponsescRNA sequencingscRNA-seqsequencing platformsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin infectionsocial rolesuppressive myeloid cellstherapeutic agent developmenttherapeutic developmenttherapeutic targettolerance to antibioticstolerate antibioticstranscriptomewhite blood cellwhite blood corpuscle
Description preview
Prosthetic joint infection (PJI) is a complication following arthroplasty that occurs in approximately 1-3% of
patients, with ~50% of cases caused by methicillin-resistant Staphylococcus aureus (S. aureus). Biofilm
formation evolves as bacteria multiply, producing a complex extracellular matrix that creates a heterogeneous
population with unique…
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