grant
Investigating the role of cGAS signaling and microglial senscence in tauopathy
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 5 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AD dementiaAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease patientAlzheimer's disease riskAlzheimer's patientAlzheimers DementiaAmentiaAmino AcidsAmmon HornAmyloid (Aβ) plaquesAmyloid PlaquesAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnti-viral ResponseAstrocytesAstrocytusAstrogliaBehavioral AssayBindingBrainBrain Nervous SystemCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCell BodyCell Communication and SignalingCell Culture TechniquesCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessClustered Regularly Interspaced Short Palindromic RepeatsCognitiveCornu AmmonisCyclic GMPCytoplasmCytosolDNADNA DamageDNA Hybridization ProbesDNA InjuryDNA ProbesDataDegenerative Neurologic DisordersDementiaDeoxyribonucleic AcidDevelopmentDiseaseDisorderElectrophysiologyElectrophysiology (science)EncephalonExposure toExtracellular SpaceGWA studyGWASGehrig's DiseaseGenesGeneticGenetic MaterialsGenome InstabilityGenomic InstabilityGliosisGuanosine Cyclic MonophosphateHippocampusHortega cellHumanIFNIFN activationImmuneImmune Cell ActivationImmune responseImmune signalingImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn VitroInflammagingInflammatory ResponseInnate Immune ResponseInnate Immune SystemIntercellular SpaceInterferon ActivationInterferonsIntracellular Communication and SignalingKnowledgeLearningLibrariesLou Gehrig DiseaseMT-bound tauMediatingMediatorMemory DeficitMemory LossMemory impairmentMiceMice MammalsMicrogliaMitochondriaMitochondrial DNAModelingModern ManMolecularMolecular InteractionMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyNon-Polyadenylated RNANuclearNucleic AcidsParalysis AgitansParkinsonParkinson DiseasePathogenesisPathogenicityPathway interactionsPhasePhenocopyPrimary ParkinsonismPrimary Senile Degenerative DementiaPublic HealthRNARNA Gene ProductsRibonucleic AcidRisk-associated variantRoleSenile PlaquesSeriesSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingStimulator of Interferon GenesStressSubcellular ProcessSynapsesSynapticSynaptic plasticitySystemTauopathiesTimeToxic effectToxicitiesViralWorkabnormal tauabnormally aggregated tau proteinage-related inflammationaging associated inflammationalzheimer riskaminoacidamyloid beta plaqueamyloid-b plaqueanti-viral immunityantiviral immunityassembloidsastrocytic gliaaβ plaquesbiological signal transductionbrain cellcGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcGMPcell culturecell culturesclustered regularly interspaced short palindromic repeats screencored plaquecyclic GMP-AMP synthase/STINGdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiffuse plaqueefficacious therapyefficacious treatmentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfilamentous tau inclusiongenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygitter cellhippocampalhost responsehuman derived pluripotent stem cellhuman diseasehuman modelhuman pluripotent stem cellhyper-phosphorylated tauhyperphosphorylated tauimmune activationimmune system responseimmunoresponseinflamm-ageinginflamm-aginginflammation associated with agingmemory declinememory dysfunctionmesogliamicroglial cellmicrogliocytemicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule associated protein tau mutationmicrotubule bound taumicrotubule-associated protein tau mutationmicrotubule-bound taumitochondrialmitochondrial dysfunctionmodel of humanmouse modelmtDNAmurine modelmutant taumutation in microtubule associated protein taumutation in microtubule-associated protein tauneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroinflammationneuroinflammatoryneurological degenerationneuron toxicityneuronalneuronal degenerationneuronal toxicityneuropathologic tauneuropathological tauneurotoxicneurotoxicitynovelpaired helical filament of taupathogenic taupathogenic tau gene mutationpathological change in taupathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseaseperivascular glial cellprimary degenerative dementiaprotective effectresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsNuc-Seqscreeningscreeningsself-aggregate tausenescencesenescentsenile dementia of the Alzheimer typesensorsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesynapsesynaptic pruningtangletautau PHFtau Proteinstau abnormalitytau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau intronic mutationtau mediated neurodegenerationtau mutationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathological changetau pathologytau pathophysiologytau polymerizationtau proteinopathytau related neurodegenerationtau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathytranscriptomicsviral detectionvirus detectionwhole genome association analysiswhole genome association studyτ Proteinsτ aggregationτ mutation
Description preview
PROJECT SUMMARY
Innate immune antiviral pathways are upregulated in Alzheimer’s disease (AD) and are thought to drive AD
pathogenesis. The specific mediators of maladaptive antiviral responses in AD are still not understood. Innate
immune system utilizes a series of nucleic acid sensors to detect viral genetic material to activate interferon…
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