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Investigating the role of cGAS signaling and microglial senscence in tauopathy

Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 5 Aug 2023Deadline 31 Jul 2025 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease patientAlzheimer's patientAlzheimers DementiaAmino AcidsAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnti-viral ResponseBehavioral AssayBrainBrain Nervous SystemCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCyclic GMPDNADegenerative Neurologic DisordersDeoxyribonucleic AcidDevelopmentDiseaseDisorderElectrophysiologyElectrophysiology (science)EncephalonGehrig's DiseaseGenesGenetic MaterialsGuanosine Cyclic MonophosphateHortega cellHumanIFNImmuneImmune signalingImmunesInnate Immune SystemInterferonsIntracellular Communication and SignalingKnowledgeLearningLou Gehrig DiseaseMT-bound tauMediatingMediatorMemory DeficitMemory impairmentMiceMice MammalsMicrogliaMitochondriaMitochondrial DNAModern ManMolecularMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyNuclearNucleic AcidsParalysis AgitansParkinsonParkinson DiseasePathogenesisPathogenicityPathway interactionsPrimary ParkinsonismPrimary Senile Degenerative DementiaPublic HealthRoleSeriesSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingStressSubcellular ProcessTauopathiesToxic effectToxicitiesViralabnormal tauaminoacidbiological signal transductioncGMPclustered regularly interspaced short palindromic repeats screendegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalefficacious therapyefficacious treatmentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsgitter cellhuman derived pluripotent stem cellhuman modelhuman pluripotent stem cellmemory dysfunctionmesogliamicroglial cellmicrogliocytemicrotubule associated protein tau mutationmicrotubule bound taumicrotubule-associated protein tau mutationmicrotubule-bound taumitochondrialmodel of humanmtDNAmutant taumutation in microtubule associated protein taumutation in microtubule-associated protein tauneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneuropathologic tauneuropathological tauneurotoxicnovelpathogenic taupathogenic tau gene mutationpathological change in taupathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseaseperivascular glial cellprimary degenerative dementiaresponsesNuc-Seqsenescencesenescentsenile dementia of the Alzheimer typesensorsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial roletautau Proteinstau abnormalitytau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau intronic mutationtau mediated neurodegenerationtau mutationtau neurodegenerative diseasetau neuropathologytau pathological changetau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathyviral detectionvirus detectionτ Proteinsτ mutation

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PROJECT SUMMARY
Innate immune antiviral pathways are upregulated in Alzheimer’s disease (AD) and are thought to drive AD
pathogenesis. The specific mediators of maladaptive antiviral responses in AD are still not understood. Innate
immune system utilizes a series of nucleic acid sensors to detect viral genetic material to activate interferon…

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