🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Investigating the Role of Cell Plasticity in Malignant Transformation
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025Active Follow-upAdenocarcinoma CellAssayBar CodesBioassayBiochemicalBioinformaticsBiological AssayCCND1 ProteinCDK Inhibitor ProteinCDK4CDK4 geneCDKI ProteinCRISPR approachCRISPR based approachCRISPR editing screenCRISPR methodCRISPR methodologyCRISPR screenCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based screenCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 screenCRISPR/Cas9 technologyCancer CauseCancer EtiologyCancer cell lineCancersCas nuclease technologyCell BodyCell CycleCell Cycle ProgressionCell Division CycleCell Division Kinase 4Cell LineCellLineCellsCessation of lifeCharacteristicsClinicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexCyclin D1Cyclin GeneCyclin Kinase InhibitorCyclin-Dependent Kinase 4Cyclin-Dependent Kinase InhibitorCyclinsDeathDiagnosisDiseaseDisease ProgressionDisorderDrug resistanceE3 LigaseE3 Ubiquitin LigaseG1/S TransitionG1/S-Specific Cyclin D1GEM modelGEMM modelGene TargetingGenesGenetic studyGenetically Engineered MouseGlobal ChangeGoalsIn VitroInvestigatorsKinasesLigaseLigase GeneLung AdenocarcinomaMalignantMalignant - descriptorMalignant CellMalignant Glandular CellMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMediatingMolecularNSCLCNSCLC - Non-Small Cell Lung CancerNeuroendocrineNeuroendocrine SystemNeurosecretory SystemsNon-Small Cell Lung CancerNon-Small-Cell Lung CarcinomaOat cell carcinomaOncogenesisOncogenicPRAD1 ProteinPSK-J3PTK InhibitorsPTK ReceptorsPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhasePhosphorylationPhosphotransferase GenePhosphotransferasesPostdocPostdoctoral FellowProcessProtein PhosphorylationProtein Tyrosine Kinase InhibitorsProteinsProto-Oncogene Proteins c-bcl-1Pulmonary CancerPulmonary malignant NeoplasmR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRelapseResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersResistanceRetinal NeuroblastomaRetinoblastomaRoleRouteSignal PathwaySmall Cell Lung CancerStrains Cell LinesStressStructureSynthetasesTK InhibitorsTestingTimeTransmembrane Receptor Protein Tyrosine KinaseTransphosphorylasesTumor Suppressor ProteinsTyrosine Kinase InhibitorTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationWorkactive followupbarcodebcl-1 Proto-Oncogene Productsbcl-1 Proto-Oncogene Proteinsbcl1 Proto-Oncogene Proteinsc-bcl-1 Proteinscancer cellcancer progressioncancer sub-typescancer subtypescancer typecareerclustered regularly interspaced short palindromic repeats screencultured cell linecyclin Ddriver lesiondriver mutationdrug resistantexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgenetically engineered mouse modelgenetically engineered murine modelgenome scalegenome-widegenomewideimprovedin vivoin vivo Modelinhibitorinsightlung cancerlung cancer celllung oat cell carcinomalung small cell neuroendocrine carcinomamalignancymouse modelmurine modelmutantneoplasm progressionneoplasm/cancerneoplastic progressionneuroendocrine cancerneuroendocrine malignancynoveloat cell cancerpathwaypatient oriented outcomespost-docpost-doctoralpost-doctoral traineepreventpreventingreceptorresearch associatesresistance mechanismresistance to Drugresistance to therapyresistantresistant mechanismresistant to Drugresistant to therapyresponserestraintretina neuroblastomaretinoblastoma pathwayretinoblastoma tumor suppressorsmall cell lung carcinomasmall cell undifferentiated carcinomasmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolesuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapy resistanttransdifferentiationtreatment resistancetumortumor progressiontumor suppressortumorigenesisubiquinationubiquitin conjugationubiquitin-protein ligase
Applications closed.
Description preview
PROJECT SUMMARY
As tumors progress, cancer cells acquire characteristics that allow them to adapt to various stresses. In fact,
one of the best predictors of patient outcome is disease stage at the time of diagnosis, as advanced tumors are
more aggressive and difficult to treat. However, the underlying mechanisms that potentiate increased cell…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click